Severe intraoperative anaphylaxis related to thymoglobulin during living donor kidney transplantation

Muhammad Irfan Saeed, Ryan D. Nicklas, Vikas Kumar, Rajan Kapoor, Imran Y. Gani

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Anaphylaxis secondary to thymoglobulin (anti-thymocyte globulin) is a rare condition that can be life threatening. Thymoglobulin is a rabbit-derived T-cell depleting polyclonal immunoglobulin. It is commonly used for induction immunosuppression and/or for treatment of acute rejection in renal transplantation. We report a case of a living kidney transplant recipient who developed intraoperative anaphylactic shock secondary to thymoglobulin. The patient had a history of pet rabbit exposure. This case report highlights the importance of prompt identification and management of intraoperative anaphylaxis, which is key to a successful outcome. Induction immunosuppression selection based on patient characteristics is important. Communication between the anesthesia team and surgeons played a key role in stopping the donor surgery.

Original languageEnglish (US)
Article number43
Pages (from-to)1-5
Number of pages5
JournalAntibodies
Volume9
Issue number3
DOIs
StatePublished - Sep 2020

Keywords

  • Anaphylactic shock
  • Living donor kidney transplantation
  • Rabbit anti-thymocyte globulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Drug Discovery

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