Sex and the kidneys: current understanding and research opportunities

on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys”

Research output: Contribution to journalReview article

Abstract

Concerns regarding sex differences are increasingly pertinent in scientific and societal arenas. Although biological sex and socio-cultural gender are increasingly recognized as important modulators of renal function under physiological and pathophysiological conditions, gaps remain in our understanding of the mechanisms underlying sex differences in renal pathophysiology, disease development, progression and management. In this Perspectives article, we discuss specific opportunities for future research aimed at addressing these knowledge gaps. Such opportunities include the development of standardized core data elements and outcomes related to sex for use in clinical studies to establish a connection between sex hormones and renal disease development or progression, development of a knowledge portal to promote fundamental understanding of physiological differences between male and female kidneys in animal models and in humans, and the creation of new or the development of existing resources and datasets to make them more readily available for interrogation of sex differences. These ideas are intended to stimulate thought and interest among the renal research community as they consider sex as a biological variable in future research projects.

Original languageEnglish (US)
Pages (from-to)776-783
Number of pages8
JournalNature Reviews Nephrology
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2019

Fingerprint

Kidney
Sex Characteristics
Research
Gonadal Steroid Hormones
Disease Management
Disease Progression
Animal Models

ASJC Scopus subject areas

  • Nephrology

Cite this

on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys” (2019). Sex and the kidneys: current understanding and research opportunities. Nature Reviews Nephrology, 15(12), 776-783. https://doi.org/10.1038/s41581-019-0208-6

Sex and the kidneys : current understanding and research opportunities. / on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys”.

In: Nature Reviews Nephrology, Vol. 15, No. 12, 01.12.2019, p. 776-783.

Research output: Contribution to journalReview article

on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys” 2019, 'Sex and the kidneys: current understanding and research opportunities', Nature Reviews Nephrology, vol. 15, no. 12, pp. 776-783. https://doi.org/10.1038/s41581-019-0208-6
on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys”. Sex and the kidneys: current understanding and research opportunities. Nature Reviews Nephrology. 2019 Dec 1;15(12):776-783. https://doi.org/10.1038/s41581-019-0208-6
on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys”. / Sex and the kidneys : current understanding and research opportunities. In: Nature Reviews Nephrology. 2019 ; Vol. 15, No. 12. pp. 776-783.
@article{403544e3fc364d85918880c4032ccfb8,
title = "Sex and the kidneys: current understanding and research opportunities",
abstract = "Concerns regarding sex differences are increasingly pertinent in scientific and societal arenas. Although biological sex and socio-cultural gender are increasingly recognized as important modulators of renal function under physiological and pathophysiological conditions, gaps remain in our understanding of the mechanisms underlying sex differences in renal pathophysiology, disease development, progression and management. In this Perspectives article, we discuss specific opportunities for future research aimed at addressing these knowledge gaps. Such opportunities include the development of standardized core data elements and outcomes related to sex for use in clinical studies to establish a connection between sex hormones and renal disease development or progression, development of a knowledge portal to promote fundamental understanding of physiological differences between male and female kidneys in animal models and in humans, and the creation of new or the development of existing resources and datasets to make them more readily available for interrogation of sex differences. These ideas are intended to stimulate thought and interest among the renal research community as they consider sex as a biological variable in future research projects.",
author = "{on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys”} and {Bairey Merz}, {C. Noel} and Dember, {Laura M.} and Ingelfinger, {Julie R.} and Amanda Vinson and Joel Neugarten and Sandberg, {Kathryn L.} and Sullivan, {Jennifer C.} and Christine Maric-Bilkan and Rankin, {Tracy L.} and Kimmel, {Paul L.} and Star, {Robert A.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41581-019-0208-6",
language = "English (US)",
volume = "15",
pages = "776--783",
journal = "Nature Reviews Nephrology",
issn = "1759-5061",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Sex and the kidneys

T2 - current understanding and research opportunities

AU - on behalf of the participants of the National Institute of Diabetes and Digestive and Kidney Diseases Workshop on “Sex and the Kidneys”

AU - Bairey Merz, C. Noel

AU - Dember, Laura M.

AU - Ingelfinger, Julie R.

AU - Vinson, Amanda

AU - Neugarten, Joel

AU - Sandberg, Kathryn L.

AU - Sullivan, Jennifer C.

AU - Maric-Bilkan, Christine

AU - Rankin, Tracy L.

AU - Kimmel, Paul L.

AU - Star, Robert A.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Concerns regarding sex differences are increasingly pertinent in scientific and societal arenas. Although biological sex and socio-cultural gender are increasingly recognized as important modulators of renal function under physiological and pathophysiological conditions, gaps remain in our understanding of the mechanisms underlying sex differences in renal pathophysiology, disease development, progression and management. In this Perspectives article, we discuss specific opportunities for future research aimed at addressing these knowledge gaps. Such opportunities include the development of standardized core data elements and outcomes related to sex for use in clinical studies to establish a connection between sex hormones and renal disease development or progression, development of a knowledge portal to promote fundamental understanding of physiological differences between male and female kidneys in animal models and in humans, and the creation of new or the development of existing resources and datasets to make them more readily available for interrogation of sex differences. These ideas are intended to stimulate thought and interest among the renal research community as they consider sex as a biological variable in future research projects.

AB - Concerns regarding sex differences are increasingly pertinent in scientific and societal arenas. Although biological sex and socio-cultural gender are increasingly recognized as important modulators of renal function under physiological and pathophysiological conditions, gaps remain in our understanding of the mechanisms underlying sex differences in renal pathophysiology, disease development, progression and management. In this Perspectives article, we discuss specific opportunities for future research aimed at addressing these knowledge gaps. Such opportunities include the development of standardized core data elements and outcomes related to sex for use in clinical studies to establish a connection between sex hormones and renal disease development or progression, development of a knowledge portal to promote fundamental understanding of physiological differences between male and female kidneys in animal models and in humans, and the creation of new or the development of existing resources and datasets to make them more readily available for interrogation of sex differences. These ideas are intended to stimulate thought and interest among the renal research community as they consider sex as a biological variable in future research projects.

UR - http://www.scopus.com/inward/record.url?scp=85074464186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074464186&partnerID=8YFLogxK

U2 - 10.1038/s41581-019-0208-6

DO - 10.1038/s41581-019-0208-6

M3 - Review article

C2 - 31586165

AN - SCOPUS:85074464186

VL - 15

SP - 776

EP - 783

JO - Nature Reviews Nephrology

JF - Nature Reviews Nephrology

SN - 1759-5061

IS - 12

ER -