TY - JOUR
T1 - Sex differences in renal mitochondrial function
T2 - A hormone-gous opportunity for research
AU - Sultanova, Regina F.
AU - Schibalski, Ryan
AU - Yankelevich, Irina A.
AU - Stadler, Krisztian
AU - Ilatovskaya, Daria V.
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) Grants R01HL148114 and R00DK105160, the Dialysis Clinic Incorporated Reserve Fund (C-4153), and the American Physiological Society Research Career Enhancement and Lazaro J Mandel awards (to D.V.I.). In addition, this work was partially supported through NIH Grants R01DK115749, P30DK072476, and a COBRE Pilot and Feasibility award (all to K.S.).
Publisher Copyright:
© 2020 American Physiological Society. All rights reserved.
PY - 2020/12/14
Y1 - 2020/12/14
N2 - Sex differences (biological distinctions between males and females) present a complex interplay of genetic, developmental, biological, and environmental factors. More and more studies are shedding light on the importance of sex differences in normal physiology and susceptibility to cancer, cardiovascular and renal conditions, and neurodegenerative diseases. This mini-review is devoted to the role of sex dimorphisms in renal function, with a focus on the distinctions between male and female mitochondria. Here, we cover the aspects of renal mitochondrial bioenergetics where sex differences have been reported to date, for instance, biogenesis, reactive oxygen species production, and oxidative stress. Special attention is devoted to the effects of sex hormones, such as estrogen and testosterone, on mitochondrial bioenergetics in the kidney in physiology and pathophysiology.
AB - Sex differences (biological distinctions between males and females) present a complex interplay of genetic, developmental, biological, and environmental factors. More and more studies are shedding light on the importance of sex differences in normal physiology and susceptibility to cancer, cardiovascular and renal conditions, and neurodegenerative diseases. This mini-review is devoted to the role of sex dimorphisms in renal function, with a focus on the distinctions between male and female mitochondria. Here, we cover the aspects of renal mitochondrial bioenergetics where sex differences have been reported to date, for instance, biogenesis, reactive oxygen species production, and oxidative stress. Special attention is devoted to the effects of sex hormones, such as estrogen and testosterone, on mitochondrial bioenergetics in the kidney in physiology and pathophysiology.
KW - Female
KW - Kidney
KW - Male
KW - Mitochondria
KW - Sex differences
UR - http://www.scopus.com/inward/record.url?scp=85098531665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85098531665&partnerID=8YFLogxK
U2 - 10.1152/AJPRENAL.00320.2020
DO - 10.1152/AJPRENAL.00320.2020
M3 - Review article
C2 - 33135479
AN - SCOPUS:85098531665
SN - 1931-857X
VL - 319
SP - F1117-F1124
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
IS - 6
ER -