Sex dimorphisms in inflammatory markers and adiposity in African-American youth

Karen H. Petty, Ke Li, Yanbin Dong, Jennifer Fortenberry, Inger Stallmann-Jorgensen, Dehuang Guo, Haidong Zhu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective. There are demonstrated sex differences in the association between adiposity and inflammation in adults. Our aim was to determine sex differences in inflammatory markers and in the association between adiposity and inflammation in a sample of African-American adolescents. Methods. Adiposity variables including body mass index (BMI), waist circumference, weight, total fat, trunk fat, and inflammatory markers including interleukin-6 (IL-6), leptin, monocyte chemotactic protein 1 (MCP1), C-reactive Protein (CRP), adiponectin were examined in 166 (53% female) African-American adolescents, aged 14-19 years. Total fat and trunk fat were measured using Dual-Energy X-Ray Absorptiometry (DXA). Results. Results revealed males had higher weight (p=0.01); females had higher BMI, trunk fat, and total fat (p's <0.01). With inflammation, males had higher MCP1 (p=0.024); females had higher leptin (p<0.001), adiponectin (p=0.006), and IL-6 (p=0.026). Partial correlations in males indicated associations of adiposity variables with leptin, adiponectin (all p's <0.01), and CRP (p<0.05); in females, leptin, CRP, and IL-6 were associated with adiposity variables (all p's <0.05). Multiple regression analyses revealed female adiposity variables predicted CRP, (R 2=0.254), IL-6 (R2=0.167), and MCP1 (R2=0.220). Adiposity variables in males predicted lower adiponectin (R2=0245). For both, leptin was predicted by adiposity (males R2=0.420 and females R2=0.410). Conclusions. Data indicate clear sex dimorphisms in the associations between inflammatory markers and adiposity in African-American adolescents, suggesting that preventive measures and treatments for adolescent obesity may need to be sex-specific.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalInternational Journal of Pediatric Obesity
Volume5
Issue number4
DOIs
StatePublished - Aug 1 2010

Fingerprint

Adiposity
Sex Characteristics
African Americans
Leptin
Fats
Adiponectin
C-Reactive Protein
Chemokine CCL2
Interleukin-6
Inflammation
Body Mass Index
Weights and Measures
Pediatric Obesity
Photon Absorptiometry
Waist Circumference
Protein C
Regression Analysis

Keywords

  • Adolescents
  • Inflammation
  • Obesity
  • Sex differences
  • Sex dimorphisms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Sex dimorphisms in inflammatory markers and adiposity in African-American youth. / Petty, Karen H.; Li, Ke; Dong, Yanbin; Fortenberry, Jennifer; Stallmann-Jorgensen, Inger; Guo, Dehuang; Zhu, Haidong.

In: International Journal of Pediatric Obesity, Vol. 5, No. 4, 01.08.2010, p. 327-333.

Research output: Contribution to journalArticle

Petty, Karen H. ; Li, Ke ; Dong, Yanbin ; Fortenberry, Jennifer ; Stallmann-Jorgensen, Inger ; Guo, Dehuang ; Zhu, Haidong. / Sex dimorphisms in inflammatory markers and adiposity in African-American youth. In: International Journal of Pediatric Obesity. 2010 ; Vol. 5, No. 4. pp. 327-333.
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T1 - Sex dimorphisms in inflammatory markers and adiposity in African-American youth

AU - Petty, Karen H.

AU - Li, Ke

AU - Dong, Yanbin

AU - Fortenberry, Jennifer

AU - Stallmann-Jorgensen, Inger

AU - Guo, Dehuang

AU - Zhu, Haidong

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AB - Objective. There are demonstrated sex differences in the association between adiposity and inflammation in adults. Our aim was to determine sex differences in inflammatory markers and in the association between adiposity and inflammation in a sample of African-American adolescents. Methods. Adiposity variables including body mass index (BMI), waist circumference, weight, total fat, trunk fat, and inflammatory markers including interleukin-6 (IL-6), leptin, monocyte chemotactic protein 1 (MCP1), C-reactive Protein (CRP), adiponectin were examined in 166 (53% female) African-American adolescents, aged 14-19 years. Total fat and trunk fat were measured using Dual-Energy X-Ray Absorptiometry (DXA). Results. Results revealed males had higher weight (p=0.01); females had higher BMI, trunk fat, and total fat (p's <0.01). With inflammation, males had higher MCP1 (p=0.024); females had higher leptin (p<0.001), adiponectin (p=0.006), and IL-6 (p=0.026). Partial correlations in males indicated associations of adiposity variables with leptin, adiponectin (all p's <0.01), and CRP (p<0.05); in females, leptin, CRP, and IL-6 were associated with adiposity variables (all p's <0.05). Multiple regression analyses revealed female adiposity variables predicted CRP, (R 2=0.254), IL-6 (R2=0.167), and MCP1 (R2=0.220). Adiposity variables in males predicted lower adiponectin (R2=0245). For both, leptin was predicted by adiposity (males R2=0.420 and females R2=0.410). Conclusions. Data indicate clear sex dimorphisms in the associations between inflammatory markers and adiposity in African-American adolescents, suggesting that preventive measures and treatments for adolescent obesity may need to be sex-specific.

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KW - Inflammation

KW - Obesity

KW - Sex differences

KW - Sex dimorphisms

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