Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals

J. A. Kanaley, T. D. Heden, Y. Liu, A. T. Whaley-Connell, A. Chockalingam, Kevin C Dellsperger, T. J. Fairchild

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Objective:Short-term exercise training improves glycemic control, but the effect of short-term training on postprandial satiety peptide responses or perceived satiety remains unknown. We tested the hypothesis that short-term aerobic exercise training (15 days) would alter postprandial pancreatic and gut peptide (pancreatic polypeptide (PP) and peptide YY (PYY)) responses and perceived appetite and satiety in obese individuals.Subjects:Thirteen healthy obese men and women (age: 42±2 years; body mass index: 30-45 kg m -2).Measurements:Subjects were studied before and after 15 days of training (walking 1 h at 70-75% VO 2peak). On the study day, subjects consumed 1500 kcal as six meals (250 kcal: 9 g protein, 40 g carbohydrate, 6 g fat), while blood samples and satiety measurements were taken at baseline and every 20 min for 12 h. Blood was analyzed for PP, PYY, glucose and insulin levels. Appetite and satiety was assessed with a visual analog scale throughout the day.Results:Incremental area under the curve (iAUC) for PP increased significantly with training (pre: 2788±753; post: 3845±830 pg ml -1 ·per min for 12 h; P<0.001), but there was no difference in the PP response to each meal. The initial PP response to the first meal increased (ΔPP min 20-0: pre 86±25; post 140±36 pg ml -1; P<0.05) with training. PYY iAUC showed no significant changes with training but showed a significant main effect of time across meals, with the largest response being to the first meal (P<0.005). There were no changes in satiety, glucose or insulin levels with training.Conclusion:Short-term exercise training increases postprandial PP concentrations in obese individuals; however, PYY levels and glycemic control remain unaffected. Both PP and PYY show meal-induced increases at all meals, but PYY has a greater response at the first meal with reduced responses at subsequent meals.

Original languageEnglish (US)
Pages (from-to)266-271
Number of pages6
JournalInternational Journal of Obesity
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • autonegative feedback
  • gut hormones
  • hunger
  • satiety
  • short-term training

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Kanaley, J. A., Heden, T. D., Liu, Y., Whaley-Connell, A. T., Chockalingam, A., Dellsperger, K. C., & Fairchild, T. J. (2014). Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals. International Journal of Obesity, 38(2), 266-271. https://doi.org/10.1038/ijo.2013.84