Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators

John K. Ma, Waleed Fouad Mourad, Robert Allbright, Satyaseelan Packianathan, Leslie M. Harrell, Edmund Chinchar, Alex Nguyen, Srinivasan Vijayakumar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To compare the short-term toxicity and dosimetry of tandem and ring (TR), and tandem and ovoid (TO) applicators in treatment of gynecologic malignancy. Material and methods: Following pelvic external beam radiation therapy (EBRT), a total of 52 computed tomography-based plans from 13 patients with cervical cancer (FIGO IB2-IIIB) were evaluated for HDR brachytherapy. Prescription was 7 Gy to the ICRU point A for four weekly fractions. Gastrointestinal and genitourinary toxicities were evaluated. Clinical target volume (CTV) and organs at risk were delineated on CT scans. Bladder, rectum, and sigmoid mean doses and D2cc were calculated. Treatment time and irradiated tissue volume were compared. Percent of CTV receiving 100% (CTV100%) of the prescribed dose as well as the percent of the prescription dose covering 90% of the CTV (D90) were evaluated. Results: Gastrointestinal and genitourinary toxicities were not different between TO and TR applicators. No significant differences in the dose to the right and left point A, or the left point B were observed. TO delivered a higher dose to right point B. Organs at risk doses were similar between the two applicators, except mean rectal dose was lower for TO applicator. Overall, TO treats a larger tissue volume than TR. Mean treatment time was shorter for TR. Tumor coverage (D90 and CTV100%) was equivalent between TO and TR applicators. Conclusion: Although TO treats a larger tissue volume than TR, short-term toxicities and tumor coverage are similar. Long-term clinical outcomes will be elucidated with longer follow up period.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalJournal of Contemporary Brachytherapy
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Organs at Risk
Prescriptions
Neoplasms
Brachytherapy
Sigmoid Colon
Rectum
Uterine Cervical Neoplasms
Urinary Bladder
Radiotherapy
Therapeutics
Tomography

Keywords

  • Brachytherapy
  • Cervical cancer
  • Dosimetry
  • Radiation toxicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Ma, J. K., Mourad, W. F., Allbright, R., Packianathan, S., Harrell, L. M., Chinchar, E., ... Vijayakumar, S. (2015). Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators. Journal of Contemporary Brachytherapy, 7(3), 218-223. https://doi.org/10.5114/jcb.2015.51853

Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators. / Ma, John K.; Mourad, Waleed Fouad; Allbright, Robert; Packianathan, Satyaseelan; Harrell, Leslie M.; Chinchar, Edmund; Nguyen, Alex; Vijayakumar, Srinivasan.

In: Journal of Contemporary Brachytherapy, Vol. 7, No. 3, 01.01.2015, p. 218-223.

Research output: Contribution to journalArticle

Ma, JK, Mourad, WF, Allbright, R, Packianathan, S, Harrell, LM, Chinchar, E, Nguyen, A & Vijayakumar, S 2015, 'Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators', Journal of Contemporary Brachytherapy, vol. 7, no. 3, pp. 218-223. https://doi.org/10.5114/jcb.2015.51853
Ma, John K. ; Mourad, Waleed Fouad ; Allbright, Robert ; Packianathan, Satyaseelan ; Harrell, Leslie M. ; Chinchar, Edmund ; Nguyen, Alex ; Vijayakumar, Srinivasan. / Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators. In: Journal of Contemporary Brachytherapy. 2015 ; Vol. 7, No. 3. pp. 218-223.
@article{bb55a1a5e36240fda54fa3fb12741a50,
title = "Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators",
abstract = "Purpose: To compare the short-term toxicity and dosimetry of tandem and ring (TR), and tandem and ovoid (TO) applicators in treatment of gynecologic malignancy. Material and methods: Following pelvic external beam radiation therapy (EBRT), a total of 52 computed tomography-based plans from 13 patients with cervical cancer (FIGO IB2-IIIB) were evaluated for HDR brachytherapy. Prescription was 7 Gy to the ICRU point A for four weekly fractions. Gastrointestinal and genitourinary toxicities were evaluated. Clinical target volume (CTV) and organs at risk were delineated on CT scans. Bladder, rectum, and sigmoid mean doses and D2cc were calculated. Treatment time and irradiated tissue volume were compared. Percent of CTV receiving 100{\%} (CTV100{\%}) of the prescribed dose as well as the percent of the prescription dose covering 90{\%} of the CTV (D90) were evaluated. Results: Gastrointestinal and genitourinary toxicities were not different between TO and TR applicators. No significant differences in the dose to the right and left point A, or the left point B were observed. TO delivered a higher dose to right point B. Organs at risk doses were similar between the two applicators, except mean rectal dose was lower for TO applicator. Overall, TO treats a larger tissue volume than TR. Mean treatment time was shorter for TR. Tumor coverage (D90 and CTV100{\%}) was equivalent between TO and TR applicators. Conclusion: Although TO treats a larger tissue volume than TR, short-term toxicities and tumor coverage are similar. Long-term clinical outcomes will be elucidated with longer follow up period.",
keywords = "Brachytherapy, Cervical cancer, Dosimetry, Radiation toxicity",
author = "Ma, {John K.} and Mourad, {Waleed Fouad} and Robert Allbright and Satyaseelan Packianathan and Harrell, {Leslie M.} and Edmund Chinchar and Alex Nguyen and Srinivasan Vijayakumar",
year = "2015",
month = "1",
day = "1",
doi = "10.5114/jcb.2015.51853",
language = "English (US)",
volume = "7",
pages = "218--223",
journal = "Journal of Contemporary Brachytherapy",
issn = "1689-832X",
publisher = "Termedia Publishing House Ltd.",
number = "3",

}

TY - JOUR

T1 - Short-term clinical outcome and dosimetric comparison of tandem and ring versus tandem and ovoids intracavitary applicators

AU - Ma, John K.

AU - Mourad, Waleed Fouad

AU - Allbright, Robert

AU - Packianathan, Satyaseelan

AU - Harrell, Leslie M.

AU - Chinchar, Edmund

AU - Nguyen, Alex

AU - Vijayakumar, Srinivasan

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: To compare the short-term toxicity and dosimetry of tandem and ring (TR), and tandem and ovoid (TO) applicators in treatment of gynecologic malignancy. Material and methods: Following pelvic external beam radiation therapy (EBRT), a total of 52 computed tomography-based plans from 13 patients with cervical cancer (FIGO IB2-IIIB) were evaluated for HDR brachytherapy. Prescription was 7 Gy to the ICRU point A for four weekly fractions. Gastrointestinal and genitourinary toxicities were evaluated. Clinical target volume (CTV) and organs at risk were delineated on CT scans. Bladder, rectum, and sigmoid mean doses and D2cc were calculated. Treatment time and irradiated tissue volume were compared. Percent of CTV receiving 100% (CTV100%) of the prescribed dose as well as the percent of the prescription dose covering 90% of the CTV (D90) were evaluated. Results: Gastrointestinal and genitourinary toxicities were not different between TO and TR applicators. No significant differences in the dose to the right and left point A, or the left point B were observed. TO delivered a higher dose to right point B. Organs at risk doses were similar between the two applicators, except mean rectal dose was lower for TO applicator. Overall, TO treats a larger tissue volume than TR. Mean treatment time was shorter for TR. Tumor coverage (D90 and CTV100%) was equivalent between TO and TR applicators. Conclusion: Although TO treats a larger tissue volume than TR, short-term toxicities and tumor coverage are similar. Long-term clinical outcomes will be elucidated with longer follow up period.

AB - Purpose: To compare the short-term toxicity and dosimetry of tandem and ring (TR), and tandem and ovoid (TO) applicators in treatment of gynecologic malignancy. Material and methods: Following pelvic external beam radiation therapy (EBRT), a total of 52 computed tomography-based plans from 13 patients with cervical cancer (FIGO IB2-IIIB) were evaluated for HDR brachytherapy. Prescription was 7 Gy to the ICRU point A for four weekly fractions. Gastrointestinal and genitourinary toxicities were evaluated. Clinical target volume (CTV) and organs at risk were delineated on CT scans. Bladder, rectum, and sigmoid mean doses and D2cc were calculated. Treatment time and irradiated tissue volume were compared. Percent of CTV receiving 100% (CTV100%) of the prescribed dose as well as the percent of the prescription dose covering 90% of the CTV (D90) were evaluated. Results: Gastrointestinal and genitourinary toxicities were not different between TO and TR applicators. No significant differences in the dose to the right and left point A, or the left point B were observed. TO delivered a higher dose to right point B. Organs at risk doses were similar between the two applicators, except mean rectal dose was lower for TO applicator. Overall, TO treats a larger tissue volume than TR. Mean treatment time was shorter for TR. Tumor coverage (D90 and CTV100%) was equivalent between TO and TR applicators. Conclusion: Although TO treats a larger tissue volume than TR, short-term toxicities and tumor coverage are similar. Long-term clinical outcomes will be elucidated with longer follow up period.

KW - Brachytherapy

KW - Cervical cancer

KW - Dosimetry

KW - Radiation toxicity

UR - http://www.scopus.com/inward/record.url?scp=84934284183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934284183&partnerID=8YFLogxK

U2 - 10.5114/jcb.2015.51853

DO - 10.5114/jcb.2015.51853

M3 - Article

AN - SCOPUS:84934284183

VL - 7

SP - 218

EP - 223

JO - Journal of Contemporary Brachytherapy

JF - Journal of Contemporary Brachytherapy

SN - 1689-832X

IS - 3

ER -