SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders

Irene Litvan, Kailash P. Bhatia, David J. Burn, Christopher G. Goetz, Anthony E. Lang, Ian McKeith, Niall Quinn, Kapil D. Sethi, Cliff Shults, Gregor K. Wenning

Research output: Contribution to journalReview article

731 Scopus citations

Abstract

As there are no biological markers for the antemortem diagnosis of degenerative parkinsonian disorders, diagnosis currently relies upon the presence and progression of clinical features and confirmation depends on neuropathology. Clinicopathologic studies have shown significant false-positive and false-negative rates for diagnosing these disorders, and misdiagnosis is especially common during the early stages of these diseases. It is important to establish a set of widely accepted diagnostic criteria for these disorders that may be applied and reproduced in a blinded fashion. This review summarizes the findings of the SIC Task Force for the study of diagnostic criteria for parkinsonian disorders in the areas of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. In each of these areas, diagnosis continues to rest on clinical findings and the judicious use of ancillary studies.

Original languageEnglish (US)
Pages (from-to)467-486
Number of pages20
JournalMovement Disorders
Volume18
Issue number5
DOIs
StatePublished - May 1 2003

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Keywords

  • Accuracy
  • Corticobasal degeneration
  • Dementia with Lewy bodies
  • Diagnostic criteria
  • Multiple system atrophy
  • Parkinson disease
  • Progressive supranuclear palsy
  • Reliability

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Litvan, I., Bhatia, K. P., Burn, D. J., Goetz, C. G., Lang, A. E., McKeith, I., Quinn, N., Sethi, K. D., Shults, C., & Wenning, G. K. (2003). SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders. Movement Disorders, 18(5), 467-486. https://doi.org/10.1002/mds.10459