Signal transduction by a protease cascade

Ellen LeMosy, Charles C. Hong, Carl Hashimoto

Research output: Contribution to journalReview article

94 Citations (Scopus)

Abstract

The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalTrends in Cell Biology
Volume9
Issue number3
DOIs
StatePublished - Mar 1 1999
Externally publishedYes

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Signal Transduction
Peptide Hydrolases
Embryonic Structures
Cues
Serine Proteases
Drosophila
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Signal transduction by a protease cascade. / LeMosy, Ellen; Hong, Charles C.; Hashimoto, Carl.

In: Trends in Cell Biology, Vol. 9, No. 3, 01.03.1999, p. 102-107.

Research output: Contribution to journalReview article

LeMosy, Ellen ; Hong, Charles C. ; Hashimoto, Carl. / Signal transduction by a protease cascade. In: Trends in Cell Biology. 1999 ; Vol. 9, No. 3. pp. 102-107.
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