Signaling complexes for postsynaptic differentiation

Zhenge Luo, Qiang Wang, G. Clement Dobbins, Shoshanah Levy, Wencheng Xiong, Lin Mei

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The receptor tyrosine kinase MuSK is activated by agrin, an extracellular matrix protein believed to be utilized by motoneurons to regulate the formation or maintenance of the neuromuscular junction (NMJ). Recent studies have shed light on intracellular signaling mechanisms downstream of MuSK. Agrin enhances the activity of Rho GTPases and PAK, which is required for AChR clustering. Activation of these enzymes requires not only the kinase activity of MuSK, but also its interaction with proteins such as Dishevelled. These results suggest that MuSK may function as a scaffold tyrosine kinase that forms a multi-molecule complex for AChR clustering.

Original languageEnglish (US)
Pages (from-to)697-708
Number of pages12
JournalJournal of Neurocytology
Volume32
Issue number5-8
DOIs
StatePublished - Jun 1 2003

Fingerprint

Agrin
Cluster Analysis
rho GTP-Binding Proteins
Enzyme Activation
Neuromuscular Junction
Extracellular Matrix Proteins
Receptor Protein-Tyrosine Kinases
Motor Neurons
Protein-Tyrosine Kinases
Phosphotransferases
Maintenance
Proteins

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology
  • Cell Biology

Cite this

Luo, Z., Wang, Q., Dobbins, G. C., Levy, S., Xiong, W., & Mei, L. (2003). Signaling complexes for postsynaptic differentiation. Journal of Neurocytology, 32(5-8), 697-708. https://doi.org/10.1023/B:NEUR.0000020618.65271.63

Signaling complexes for postsynaptic differentiation. / Luo, Zhenge; Wang, Qiang; Dobbins, G. Clement; Levy, Shoshanah; Xiong, Wencheng; Mei, Lin.

In: Journal of Neurocytology, Vol. 32, No. 5-8, 01.06.2003, p. 697-708.

Research output: Contribution to journalReview article

Luo, Z, Wang, Q, Dobbins, GC, Levy, S, Xiong, W & Mei, L 2003, 'Signaling complexes for postsynaptic differentiation', Journal of Neurocytology, vol. 32, no. 5-8, pp. 697-708. https://doi.org/10.1023/B:NEUR.0000020618.65271.63
Luo, Zhenge ; Wang, Qiang ; Dobbins, G. Clement ; Levy, Shoshanah ; Xiong, Wencheng ; Mei, Lin. / Signaling complexes for postsynaptic differentiation. In: Journal of Neurocytology. 2003 ; Vol. 32, No. 5-8. pp. 697-708.
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