Simulating leukocyte-venule interactions - A novel agent-oriented approach

J. Tang, C. A. Hunt, J. Mellein, K. Ley

Research output: Contribution to journalConference articlepeer-review

13 Scopus citations

Abstract

Leukocyte recruitment into sites of inflammation involves a complex cascade of molecular interactions between the leukocyte and the endothelial cells of the inflamed venule. This report proposes a novel agent-oriented approach for simulating leukocyte-venule interactions during inflammation. We focus on modeling and simulating the initial steps of rolling, activation, and firm adhesion of neutrophils on TNF-α-treated mouse cremaster muscle venules.

Original languageEnglish (US)
Pages (from-to)4978-4981
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 VII
StatePublished - 2004
Externally publishedYes
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Keywords

  • Adhesion
  • Agent-Based Model
  • Endothelium
  • Inflammation
  • Leukocyte
  • Rolling
  • Transmigration

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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