TY - JOUR
T1 - Single nucleotide polymorphism in β2-adrenoceptor gene and the distribution in Chinese Han ethnic group
AU - Wu, H.
AU - Cai, G.
AU - Xu, Hongyan
AU - Chen, H.
AU - Xiao, J.
AU - Lu, D.
AU - Xue, J.
AU - Qiu, X.
AU - Jin, L.
PY - 2001
Y1 - 2001
N2 - Objective The study was conducted to investigate single nucleotide polymorphism (SNP) in beta2-adrenoceptor (β2-AR) gene and the distribution of these identified SNPs in Chinese Han ethnic group. Methods β2-AR gene was sequenced to detect SNPs by fluorescent labeling automatic sequencing method in 80 unrelated samples from territory of Dabie Mountain in Anhui province. Results A total of 8 SNPs were identified in length of 3, 8 kb, including 5 SNPs in code region, 3 SNPs in regulatory region. Although the variations, -468C to G, -367T to C, -47C to T, -20T to C, +79C to G, +100G to A, +491C to T, +1098T to C have been identified in other ethnic groups, they have not been found in our study. The allele distribution of SNPs is in good unity with the Hardy-Weinberg equilibrium. Conclusion The distribution of SNPs in β2-AR gene is not equable and the SNPs in different ethnic groups differ greatly. The allele distribution of SNPs conforms well to the Hardy-Weinberg equilibrium.
AB - Objective The study was conducted to investigate single nucleotide polymorphism (SNP) in beta2-adrenoceptor (β2-AR) gene and the distribution of these identified SNPs in Chinese Han ethnic group. Methods β2-AR gene was sequenced to detect SNPs by fluorescent labeling automatic sequencing method in 80 unrelated samples from territory of Dabie Mountain in Anhui province. Results A total of 8 SNPs were identified in length of 3, 8 kb, including 5 SNPs in code region, 3 SNPs in regulatory region. Although the variations, -468C to G, -367T to C, -47C to T, -20T to C, +79C to G, +100G to A, +491C to T, +1098T to C have been identified in other ethnic groups, they have not been found in our study. The allele distribution of SNPs is in good unity with the Hardy-Weinberg equilibrium. Conclusion The distribution of SNPs in β2-AR gene is not equable and the SNPs in different ethnic groups differ greatly. The allele distribution of SNPs conforms well to the Hardy-Weinberg equilibrium.
KW - Gene
KW - Genetics
KW - Single nucleotide polymorphism
KW - β-adrenoceptor
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M3 - Article
C2 - 11172630
AN - SCOPUS:0035114189
SN - 1003-9406
VL - 18
SP - 1
EP - 3
JO - Chinese Journal of Medical Genetics
JF - Chinese Journal of Medical Genetics
IS - 1
ER -