Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner

Joseph R. Tucci, Gary M. Whitford, William H. McAlister, Deborah V. Novack, Steven Mumm, Tony M. Keaveny, Michael P. Whyte

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Skeletal fluorosis (SF) is endemic in many countries and millions of people are affected worldwide, whereas in the United States SF is rare with occasional descriptions of unique cases. We report a 28-year-old American man who was healthy until 2 years earlier when he gradually experienced difficulty walking and an abnormal gait, left hip pain, loss of mobility in his right wrist and forearm, and progressive deformities including enlargement of the digits of both hands. Dual-energy X-ray absorptiometry (DXA) of his lumbar spine, femoral neck, total hip, and the one-third forearm revealed bone mineral density (BMD) Z-scores of +6.2, +4.8, +3.0, and –0.2, respectively. Serum, urine, and bone fluoride levels were all elevated and ultimately explained by chronic sniffing abuse of a computer cleaner containing 1,1-difluoroethane. Our findings reflect SF due to the unusual cause of inhalation abuse of difluoroethane. Because this practice seems widespread, particularly in the young, there may be many more such cases.

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalJournal of Bone and Mineral Research
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Forearm
Inhalation
Hip
Mobility Limitation
Femur Neck
Photon Absorptiometry
Wrist
Fluorides
Gait
Bone Density
Spine
Hand
Urine
Bone and Bones
Pain
Serum
1,1-difluoroethane

Keywords

  • FLUORIDE
  • HYPEROSTOSIS
  • OSTEOSCLEROSIS
  • PERIOSTITIS

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner. / Tucci, Joseph R.; Whitford, Gary M.; McAlister, William H.; Novack, Deborah V.; Mumm, Steven; Keaveny, Tony M.; Whyte, Michael P.

In: Journal of Bone and Mineral Research, Vol. 32, No. 1, 01.01.2017, p. 188-195.

Research output: Contribution to journalArticle

Tucci, Joseph R. ; Whitford, Gary M. ; McAlister, William H. ; Novack, Deborah V. ; Mumm, Steven ; Keaveny, Tony M. ; Whyte, Michael P. / Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner. In: Journal of Bone and Mineral Research. 2017 ; Vol. 32, No. 1. pp. 188-195.
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