Skeletal fluorosis from brewed tea

Kenneth Izuora, Jennifer G. Twombly, Gary M. Whitford, Jennifer Demertzis, Roberto Pacifici, Michael P. Whyte

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: High fluoride ion (F -) levels are found in many surface and well waters. Drinking F --contaminated water typically explains endemic skeletal fluorosis (SF). In some regions of Asia, however, poor quality "brick tea" also causes this disorder. The plant source of brick, black, green, orange pekoe, and oolong tea, Camellia sinensis, can contain substantial amounts of F -. Exposure to 20 mg F - per day for 20 yr of adult life is expected to cause symptomatic SF. High F - levels stimulate osteoblasts and enhance bone apposition but substitute for OH - groups in hydroxyapatite crystals and thereby result in skeletal fragility and perhaps lead to secondary hyperparathyroidism. Beginning in 2005, we showed that daily consumption of 1-2 gallons of instant tea made from this plant can lead to SF. Aim: We describe a 48-yr-old American woman who developed SF from brewed tea. Patient and Methods: Our patient had elevated bone mineral density revealed by dual-energy x-ray absorptiometry (spine Z-score, +9.9), severe chronic bone and joint pain, and kyphosis after consuming 1-2 gallons of brewed orange pekoe tea daily for more than three decades. F - levels were high in her serum, urine, and clippings of fingernails and toenails, as well as in our reproduction of her beverage. Renal function was normal. She had vitamin D deficiency. Elevated serum PTH levels were unresponsive to adequate vitamin D supplementation. Pain resolved over several months when she stopped drinking tea and continued ergocalciferol. Conclusion: Our patient shows that SF can result from chronic consumption of large volumes of brewed tea.

Original languageEnglish (US)
Pages (from-to)2318-2324
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number8
DOIs
StatePublished - Aug 1 2011

Fingerprint

Tea
Nails
Brick
Vitamin D
Drinking
Bone
Camellia sinensis
Ergocalciferols
Bone Substitutes
Kyphosis
Secondary Hyperparathyroidism
Vitamin D Deficiency
Beverages
Water
Osteoblasts
Arthralgia
Durapatite
Serum
Fluorides
Chronic Pain

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Izuora, K., Twombly, J. G., Whitford, G. M., Demertzis, J., Pacifici, R., & Whyte, M. P. (2011). Skeletal fluorosis from brewed tea. Journal of Clinical Endocrinology and Metabolism, 96(8), 2318-2324. https://doi.org/10.1210/jc.2010-2891

Skeletal fluorosis from brewed tea. / Izuora, Kenneth; Twombly, Jennifer G.; Whitford, Gary M.; Demertzis, Jennifer; Pacifici, Roberto; Whyte, Michael P.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 8, 01.08.2011, p. 2318-2324.

Research output: Contribution to journalArticle

Izuora, K, Twombly, JG, Whitford, GM, Demertzis, J, Pacifici, R & Whyte, MP 2011, 'Skeletal fluorosis from brewed tea', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 8, pp. 2318-2324. https://doi.org/10.1210/jc.2010-2891
Izuora K, Twombly JG, Whitford GM, Demertzis J, Pacifici R, Whyte MP. Skeletal fluorosis from brewed tea. Journal of Clinical Endocrinology and Metabolism. 2011 Aug 1;96(8):2318-2324. https://doi.org/10.1210/jc.2010-2891
Izuora, Kenneth ; Twombly, Jennifer G. ; Whitford, Gary M. ; Demertzis, Jennifer ; Pacifici, Roberto ; Whyte, Michael P. / Skeletal fluorosis from brewed tea. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 8. pp. 2318-2324.
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