(1-14C)-palmitate oxidation in rat skeletal muscle homogenates increased only minimally from birth until 15 days of age and then increased more than five times between 15 days and adulthood. In contrast, liver oxidation of palmitate reached adult levels by 4 days of age. Although muscle carnitine concentration, carnitine palmityl transferase activity, and total muscle protein increased during the neonatal period, these changes did not completely parallel the rise in muscle palmitate oxidation. Palmityl-CoA synthetase and pal- mityl-CoA dehydrogenase activities also did not parallel the rise in overall palmitate oxidation.
- Carnitine palmityl transferase
- Fatty acid oxidation
- Rat carnitine
- Skeletal muscle
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology