Skeletal myoblasts for cardiac repair

Shazia Durrani, Mikhail Konoplyannikov, Muhammad Ashraf, Khawaja Husnain Haider

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Stem cells provide an alternative curative intervention for the infarcted heart by compensating for the cardiomyocyte loss subsequent to myocardial injury. The presence of resident stem and progenitor cell populations in the heart, and nuclear reprogramming of somatic cells with genetic induction of pluripotency markers are the emerging new developments in stem cell-based regenerative medicine. However, until safety and feasibility of these cells are established by extensive experimentation in in vitro and in vivo experimental models, skeletal muscle-derived myoblasts, and bone marrow cells remain the most well-studied donor cell types for myocardial regeneration and repair. This article provides a critical review of skeletal myoblasts as donor cells for transplantation in the light of published experimental and clinical data, and indepth discussion of the advantages and disadvantages of skeletal myoblast-based therapeutic intervention for augmentation of myocardial function in the infarcted heart. Furthermore, strategies to overcome the problems of arrhythmogenicity and failure of the transplanted skeletal myoblasts to integrate with the host cardiomyocytes are discussed.

Original languageEnglish (US)
Pages (from-to)919-932
Number of pages14
JournalRegenerative Medicine
Volume5
Issue number6
DOIs
StatePublished - Nov 2010

Keywords

  • heart
  • myoblast
  • myocardium
  • stem cell

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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