SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter

Naren Gupta, Pamela Moore Martin, Puttur D Prasad, Vadivel Ganapathy

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

The identification of SLC5A8 as a tumor suppressor gene in colorectal cancer marks, for the first time, the association of a plasma membrane transporter with tumor suppressive properties. The subsequent establishment of the functional identity of SLC5A8 as a Na+-coupled transporter for short-chain monocarboxylates provides a mechanism for the tumor suppressive function of the transporter. Butyrate, a substrate for the transporter, is a histone deacetylase inhibitor and protective against colorectal cancer. This fatty acid is produced in the colonic lumen by bacterial fermentation of dietary fiber. SLC5A8 mediates the concentrative entry of butyrate from the lumen into colonocytes. Consequently, the transport function of SLC5A8 has the ability to influence the acetylation status of histones and hence gene expression in colonocytes. The ability of SLC5A8 to deliver butyrate into colonic epithelial cells most likely underlies the tumor suppressive role of this transporter.

Original languageEnglish (US)
Pages (from-to)2419-2425
Number of pages7
JournalLife Sciences
Volume78
Issue number21
DOIs
StatePublished - Apr 18 2006

Fingerprint

Butyrates
Tumors
Colorectal Neoplasms
Neoplasms
Histone Deacetylase Inhibitors
Membrane Transport Proteins
Dietary Fiber
Acetylation
Tumor Suppressor Genes
Histones
Fermentation
Fatty Acids
Cell membranes
Epithelial Cells
Cell Membrane
Gene expression
Gene Expression
Genes
Association reactions
Substrates

Keywords

  • Butyrate
  • Colon cancer
  • Colonic bacteria
  • Dietary fiber
  • Histone deacetylases
  • Short-chain fatty acids
  • SLC5A8

ASJC Scopus subject areas

  • Pharmacology

Cite this

SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. / Gupta, Naren; Martin, Pamela Moore; Prasad, Puttur D; Ganapathy, Vadivel.

In: Life Sciences, Vol. 78, No. 21, 18.04.2006, p. 2419-2425.

Research output: Contribution to journalReview article

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