Sleep disorders: A risk factor for normal-tension glaucoma?

Dennis M. Marcus, Anastasios P. Costarides, Parag Gokhale, Georgios Papastergiou, John J. Miller, Maribeth H Johnson, Bashir A. Chaudhary

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the prevalence of sleep-related symptoms and sleep-related breathing disorders by polysomnography in patients with normal-tension glaucoma (NTG). Patients and Methods: This comparative case series included 23 patients with NTG, 14 NTG suspects, and 30 comparison patients without NTG. A sleep history was obtained and determined to be positive or negative. Polysomnography was offered for patients with a positive sleep history. Prevalence of a positive sleep history and prevalence of sleep disorders were the main outcome measures. Results: The NTG, NTG suspect, and comparison groups did not differ with respect to age, body mass index, systemic disease, gender, or race. Thirteen (57%) of 23 patients with NTG, 6 (43%) of 14 NTG suspects, and 1 (3%) of 30 comparison patients had a positive sleep history (P = 0.001). Nine of 13 patients with NTG and four of six NTG suspects with a positive sleep history chose to undergo polysomnography. Seven (78%) of nine patients with NTG and all four NTG suspects undergoing polysomnography were diagnosed with a sleep disorder. Five patients with NTG had sleep apnea and two had sleep hypopnea. Two NTG suspects had sleep apnea; one had sleep hypopnea; and one had upper airway resistance syndrome. The one comparison patient with a positive sleep history had upper airway resistance syndrome by polysomnography. Conclusions: Sleep-disturbed breathing may be a risk factor for NTG. Although we do not provide evidence for a cause-and-effect relationship, various physiologic factors produced by sleep-disturbed breathing may play a significant role in the pathogenesis of this optic neuropathy. We recommend obtaining a sleep history from patients with NTG and performing polysomnography in those patients with sleep disturbance symptoms.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalJournal of Glaucoma
Volume10
Issue number3
DOIs
StatePublished - Jan 1 2001

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Low Tension Glaucoma
Sleep
Polysomnography
Sleep Apnea Syndromes
Respiration
Airway Resistance
Sleep Wake Disorders
Optic Nerve Diseases

Keywords

  • Low-tension glaucoma
  • Normal-tension glaucoma
  • Sleep apnea
  • Sleep disorders

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Marcus, D. M., Costarides, A. P., Gokhale, P., Papastergiou, G., Miller, J. J., Johnson, M. H., & Chaudhary, B. A. (2001). Sleep disorders: A risk factor for normal-tension glaucoma? Journal of Glaucoma, 10(3), 177-183. https://doi.org/10.1097/00061198-200106000-00006

Sleep disorders : A risk factor for normal-tension glaucoma? / Marcus, Dennis M.; Costarides, Anastasios P.; Gokhale, Parag; Papastergiou, Georgios; Miller, John J.; Johnson, Maribeth H; Chaudhary, Bashir A.

In: Journal of Glaucoma, Vol. 10, No. 3, 01.01.2001, p. 177-183.

Research output: Contribution to journalArticle

Marcus, DM, Costarides, AP, Gokhale, P, Papastergiou, G, Miller, JJ, Johnson, MH & Chaudhary, BA 2001, 'Sleep disorders: A risk factor for normal-tension glaucoma?', Journal of Glaucoma, vol. 10, no. 3, pp. 177-183. https://doi.org/10.1097/00061198-200106000-00006
Marcus DM, Costarides AP, Gokhale P, Papastergiou G, Miller JJ, Johnson MH et al. Sleep disorders: A risk factor for normal-tension glaucoma? Journal of Glaucoma. 2001 Jan 1;10(3):177-183. https://doi.org/10.1097/00061198-200106000-00006
Marcus, Dennis M. ; Costarides, Anastasios P. ; Gokhale, Parag ; Papastergiou, Georgios ; Miller, John J. ; Johnson, Maribeth H ; Chaudhary, Bashir A. / Sleep disorders : A risk factor for normal-tension glaucoma?. In: Journal of Glaucoma. 2001 ; Vol. 10, No. 3. pp. 177-183.
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abstract = "Purpose: To determine the prevalence of sleep-related symptoms and sleep-related breathing disorders by polysomnography in patients with normal-tension glaucoma (NTG). Patients and Methods: This comparative case series included 23 patients with NTG, 14 NTG suspects, and 30 comparison patients without NTG. A sleep history was obtained and determined to be positive or negative. Polysomnography was offered for patients with a positive sleep history. Prevalence of a positive sleep history and prevalence of sleep disorders were the main outcome measures. Results: The NTG, NTG suspect, and comparison groups did not differ with respect to age, body mass index, systemic disease, gender, or race. Thirteen (57{\%}) of 23 patients with NTG, 6 (43{\%}) of 14 NTG suspects, and 1 (3{\%}) of 30 comparison patients had a positive sleep history (P = 0.001). Nine of 13 patients with NTG and four of six NTG suspects with a positive sleep history chose to undergo polysomnography. Seven (78{\%}) of nine patients with NTG and all four NTG suspects undergoing polysomnography were diagnosed with a sleep disorder. Five patients with NTG had sleep apnea and two had sleep hypopnea. Two NTG suspects had sleep apnea; one had sleep hypopnea; and one had upper airway resistance syndrome. The one comparison patient with a positive sleep history had upper airway resistance syndrome by polysomnography. Conclusions: Sleep-disturbed breathing may be a risk factor for NTG. Although we do not provide evidence for a cause-and-effect relationship, various physiologic factors produced by sleep-disturbed breathing may play a significant role in the pathogenesis of this optic neuropathy. We recommend obtaining a sleep history from patients with NTG and performing polysomnography in those patients with sleep disturbance symptoms.",
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