Small bowel adenocarcinoma complicating Crohn's disease

Case series and review of the literature

Lesly A. Dossett, Lisa M. White, Dereck C. Welch, Alan J. Herline, Roberta L. Muldoon, David A. Schwartz, Paul E. Wise

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Colonic adenocarcinoma frequently complicates inflammatory bowel disease of the colon, but small bowel adenocarcinoma (SBA) is a rare complication of Crohn's disease (CD). We present two patients with SBA in CD and review the literature with regards to CD-related SBA. A 45-year-old male with a 17-year history of ileal CD presented with obstructive symptoms but no radiographic evidence of a mass. After laparoscopic ileocolectomy and repair of incidental ileosigmoid fistula, pathology showed a T3N0 adenocarcinoma within the ileal CD. Two years after his resection he was without evidence of disease. A 59-year-old male with a 15-year history of CD presented with an acute exacerbation. Small bowel follow through demonstrated a long ileal stricture for which he underwent an ileocolic resection. Postoperative pathology confirmed a T3N1 CD-related SBA. He died from metastatic cancer 3 months later. Review of the literature identified 154 cases of SBA complicating CD with several distinguishing features from de novo SBA. Patients with SBA and CD are, as a group, younger and more likely to be male. SBA is rarely diagnosed preoperatively in these patients, and has a poor prognosis due to its advanced stage at diagnosis.

Original languageEnglish (US)
Pages (from-to)1181-1187
Number of pages7
JournalAmerican Surgeon
Volume73
Issue number11
StatePublished - Nov 1 2007
Externally publishedYes

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Crohn Disease
Adenocarcinoma
Ileal Diseases
Pathology
Inflammatory Bowel Diseases
Fistula
Pathologic Constriction
Colon

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Dossett, L. A., White, L. M., Welch, D. C., Herline, A. J., Muldoon, R. L., Schwartz, D. A., & Wise, P. E. (2007). Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature. American Surgeon, 73(11), 1181-1187.

Small bowel adenocarcinoma complicating Crohn's disease : Case series and review of the literature. / Dossett, Lesly A.; White, Lisa M.; Welch, Dereck C.; Herline, Alan J.; Muldoon, Roberta L.; Schwartz, David A.; Wise, Paul E.

In: American Surgeon, Vol. 73, No. 11, 01.11.2007, p. 1181-1187.

Research output: Contribution to journalReview article

Dossett, LA, White, LM, Welch, DC, Herline, AJ, Muldoon, RL, Schwartz, DA & Wise, PE 2007, 'Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature', American Surgeon, vol. 73, no. 11, pp. 1181-1187.
Dossett LA, White LM, Welch DC, Herline AJ, Muldoon RL, Schwartz DA et al. Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature. American Surgeon. 2007 Nov 1;73(11):1181-1187.
Dossett, Lesly A. ; White, Lisa M. ; Welch, Dereck C. ; Herline, Alan J. ; Muldoon, Roberta L. ; Schwartz, David A. ; Wise, Paul E. / Small bowel adenocarcinoma complicating Crohn's disease : Case series and review of the literature. In: American Surgeon. 2007 ; Vol. 73, No. 11. pp. 1181-1187.
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