Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature

Lesly A. Dossett, Lisa M. White, Dereck C. Welch, Alan J. Herline, Roberta L. Muldoon, David A. Schwartz, Paul E. Wise

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Colonic adenocarcinoma frequently complicates inflammatory bowel disease of the colon, but small bowel adenocarcinoma (SBA) is a rare complication of Crohn's disease (CD). We present two patients with SBA in CD and review the literature with regards to CD-related SBA. A 45-year-old male with a 17-year history of ileal CD presented with obstructive symptoms but no radiographic evidence of a mass. After laparoscopic ileocolectomy and repair of incidental ileosigmoid fistula, pathology showed a T3N0 adenocarcinoma within the ileal CD. Two years after his resection he was without evidence of disease. A 59-year-old male with a 15-year history of CD presented with an acute exacerbation. Small bowel follow through demonstrated a long ileal stricture for which he underwent an ileocolic resection. Postoperative pathology confirmed a T3N1 CD-related SBA. He died from metastatic cancer 3 months later. Review of the literature identified 154 cases of SBA complicating CD with several distinguishing features from de novo SBA. Patients with SBA and CD are, as a group, younger and more likely to be male. SBA is rarely diagnosed preoperatively in these patients, and has a poor prognosis due to its advanced stage at diagnosis.

Original languageEnglish (US)
Pages (from-to)1181-1187
Number of pages7
JournalAmerican Surgeon
Volume73
Issue number11
StatePublished - Nov 1 2007

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Crohn Disease
Adenocarcinoma
Ileal Diseases
Pathology
Inflammatory Bowel Diseases
Fistula
Pathologic Constriction
Colon

ASJC Scopus subject areas

  • Surgery

Cite this

Dossett, L. A., White, L. M., Welch, D. C., Herline, A. J., Muldoon, R. L., Schwartz, D. A., & Wise, P. E. (2007). Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature. American Surgeon, 73(11), 1181-1187.

Small bowel adenocarcinoma complicating Crohn's disease : Case series and review of the literature. / Dossett, Lesly A.; White, Lisa M.; Welch, Dereck C.; Herline, Alan J.; Muldoon, Roberta L.; Schwartz, David A.; Wise, Paul E.

In: American Surgeon, Vol. 73, No. 11, 01.11.2007, p. 1181-1187.

Research output: Contribution to journalReview article

Dossett, LA, White, LM, Welch, DC, Herline, AJ, Muldoon, RL, Schwartz, DA & Wise, PE 2007, 'Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature', American Surgeon, vol. 73, no. 11, pp. 1181-1187.
Dossett LA, White LM, Welch DC, Herline AJ, Muldoon RL, Schwartz DA et al. Small bowel adenocarcinoma complicating Crohn's disease: Case series and review of the literature. American Surgeon. 2007 Nov 1;73(11):1181-1187.
Dossett, Lesly A. ; White, Lisa M. ; Welch, Dereck C. ; Herline, Alan J. ; Muldoon, Roberta L. ; Schwartz, David A. ; Wise, Paul E. / Small bowel adenocarcinoma complicating Crohn's disease : Case series and review of the literature. In: American Surgeon. 2007 ; Vol. 73, No. 11. pp. 1181-1187.
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