Small intestinal bacterial overgrowth

Duodenal aspiration vs glucose breath test

A. Erdogan, Satish Sanku Chander Rao, D. Gulley, C. Jacobs, Y. Y. Lee, C. Badger

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: The diagnosis of small intestinal bacterial overgrowth (SIBO) remains challenging. Our aim was to examine the diagnostic yield of duodenal aspiration/culture and glucose breath test (GBT), and effects of gender, race and demographics on prevalence of SIBO. Methods: Patients with unexplained gas, bloating and diarrhea and negative endoscopy, imaging and blood tests were prospectively enrolled in two centers in USA. Randomly, within 1 week each patient underwent both duodenal aspiration/culture and GBT. The diagnostic yield of each test and relationship of symptoms, and effects of ethnicity, age, and gender on prevalence of SIBO were assessed and compared. Key Results: Duodenal culture was positive in 62/139 (44.6%) subjects and GBT was positive in 38/139 (27.3%) subjects with an overall diagnostic agreement of 65.5%. The sensitivity, specificity, positive and negative predictive value of GBT was 42%, 84%, 68%, and 64%, respectively. Ethnicity or gender did not influence SIBO, but SIBO positive patients were older (p = 0.0018). Symptom patterns were similar except bloating was more prevalent in GBT positive and gas in culture positive subjects. Conclusions & Inferences: Duodenal aspiration/culture identifies 45% of patients with suspected SIBO. GBT has lower sensitivity but good specificity for detection of SIBO. There were no ethnic or gender differences in the prevalence of SIBO, but patients with SIBO were older. Because GBT is non-invasive, it should be considered first in patients with suspected SIBO.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalNeurogastroenterology and Motility
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2015

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Breath Tests
Glucose
Gases
Sensitivity and Specificity
Hematologic Tests
Endoscopy
Diarrhea
Demography

Keywords

  • Duodenal culture
  • Ethnics
  • Glucose breath test
  • Sensitivity and specificity
  • Small intestinal bacterial overgrowth

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Small intestinal bacterial overgrowth : Duodenal aspiration vs glucose breath test. / Erdogan, A.; Rao, Satish Sanku Chander; Gulley, D.; Jacobs, C.; Lee, Y. Y.; Badger, C.

In: Neurogastroenterology and Motility, Vol. 27, No. 4, 01.04.2015, p. 481-489.

Research output: Contribution to journalArticle

Erdogan, A. ; Rao, Satish Sanku Chander ; Gulley, D. ; Jacobs, C. ; Lee, Y. Y. ; Badger, C. / Small intestinal bacterial overgrowth : Duodenal aspiration vs glucose breath test. In: Neurogastroenterology and Motility. 2015 ; Vol. 27, No. 4. pp. 481-489.
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abstract = "Background: The diagnosis of small intestinal bacterial overgrowth (SIBO) remains challenging. Our aim was to examine the diagnostic yield of duodenal aspiration/culture and glucose breath test (GBT), and effects of gender, race and demographics on prevalence of SIBO. Methods: Patients with unexplained gas, bloating and diarrhea and negative endoscopy, imaging and blood tests were prospectively enrolled in two centers in USA. Randomly, within 1 week each patient underwent both duodenal aspiration/culture and GBT. The diagnostic yield of each test and relationship of symptoms, and effects of ethnicity, age, and gender on prevalence of SIBO were assessed and compared. Key Results: Duodenal culture was positive in 62/139 (44.6{\%}) subjects and GBT was positive in 38/139 (27.3{\%}) subjects with an overall diagnostic agreement of 65.5{\%}. The sensitivity, specificity, positive and negative predictive value of GBT was 42{\%}, 84{\%}, 68{\%}, and 64{\%}, respectively. Ethnicity or gender did not influence SIBO, but SIBO positive patients were older (p = 0.0018). Symptom patterns were similar except bloating was more prevalent in GBT positive and gas in culture positive subjects. Conclusions & Inferences: Duodenal aspiration/culture identifies 45{\%} of patients with suspected SIBO. GBT has lower sensitivity but good specificity for detection of SIBO. There were no ethnic or gender differences in the prevalence of SIBO, but patients with SIBO were older. Because GBT is non-invasive, it should be considered first in patients with suspected SIBO.",
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