So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin

S. A. Yousem, M. R. Wick, Gurmukh Singh, S. L. Katyal, J. C. Manivel, S. E. Mills, J. Legier

Research output: Contribution to journalArticle

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Abstract

Sclerosing hemangiomas are benign pulmonary neoplasms. They were initially believed by Liebow and Hubbell to be of endothelial origin; however, subsequent ultrastructural studies have suggested an alveolar pneumocyte and mesothelial derivation. Using a panel of various antibodies on eight cases, the authors found that sclerosing hemangiomas expressed cytokeratin (seven cases), epithelial membrane antigen (seven cases), carcinoembryonic antigen (five cases), vimentin (seven cases), surfactant apoprotein (eight cases), and Clara cell antigen (five cases). These results support the hypothesis that sclerosing hemangiomas represent an epithelial tumor showing simultaneous bronchiolar epithelial and alveolar pneumocyte differentiation.

Original languageEnglish (US)
Pages (from-to)582-590
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume12
Issue number8
StatePublished - Jan 1 1988

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Pulmonary Sclerosing Hemangioma
Benign Fibrous Histiocytoma
Alveolar Epithelial Cells
Mucin-1
Apoproteins
Carcinoembryonic Antigen
Vimentin
Keratins
Surface-Active Agents
Lung Neoplasms
Neoplasms
Antibodies

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Yousem, S. A., Wick, M. R., Singh, G., Katyal, S. L., Manivel, J. C., Mills, S. E., & Legier, J. (1988). So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin. American Journal of Surgical Pathology, 12(8), 582-590.

So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin. / Yousem, S. A.; Wick, M. R.; Singh, Gurmukh; Katyal, S. L.; Manivel, J. C.; Mills, S. E.; Legier, J.

In: American Journal of Surgical Pathology, Vol. 12, No. 8, 01.01.1988, p. 582-590.

Research output: Contribution to journalArticle

Yousem, SA, Wick, MR, Singh, G, Katyal, SL, Manivel, JC, Mills, SE & Legier, J 1988, 'So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin', American Journal of Surgical Pathology, vol. 12, no. 8, pp. 582-590.
Yousem, S. A. ; Wick, M. R. ; Singh, Gurmukh ; Katyal, S. L. ; Manivel, J. C. ; Mills, S. E. ; Legier, J. / So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin. In: American Journal of Surgical Pathology. 1988 ; Vol. 12, No. 8. pp. 582-590.
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