So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin

S. A. Yousem, M. R. Wick, G. Singh, S. L. Katyal, J. C. Manivel, S. E. Mills, J. Legier

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Sclerosing hemangiomas are benign pulmonary neoplasms. They were initially believed by Liebow and Hubbell to be of endothelial origin; however, subsequent ultrastructural studies have suggested an alveolar pneumocyte and mesothelial derivation. Using a panel of various antibodies on eight cases, the authors found that sclerosing hemangiomas expressed cytokeratin (seven cases), epithelial membrane antigen (seven cases), carcinoembryonic antigen (five cases), vimentin (seven cases), surfactant apoprotein (eight cases), and Clara cell antigen (five cases). These results support the hypothesis that sclerosing hemangiomas represent an epithelial tumor showing simultaneous bronchiolar epithelial and alveolar pneumocyte differentiation.

Original languageEnglish (US)
Pages (from-to)582-590
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume12
Issue number8
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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    Yousem, S. A., Wick, M. R., Singh, G., Katyal, S. L., Manivel, J. C., Mills, S. E., & Legier, J. (1988). So-called sclerosing hemangiomas of lung. An immunohistochemical study supporting a respiratory epithelial origin. American Journal of Surgical Pathology, 12(8), 582-590.