Solubility of injectable valium in intravenous solutions

M. F. Grower, E. A. Russell, Lee Getter

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A study of the solubility of valium in commonly used intraveous solutions showed valium to be equally insoluble in 5% dextrose in normal saline, 5% dextrose in water, normal saline, and Ringer's lactate. However, the precipitate which was formed became completely resuspended when mixed with as little as 39-42% plasma in vitro. This would indicate that the chalky precipitate seen in the i.v. tubing when valium is injected into a running i.v. near the venipuncture site becomes resuspended when mixed with plasma in vivo. If one elects to inject valium into the tubing of a running i.v., it is recommended that the drug be administered slowly to assure adequate mixing with blood plasma in order to prevent the circulation of particulate matter.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalAnesthesia Progress
Volume25
Issue number5
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Grower, M. F., Russell, E. A., & Getter, L. (1978). Solubility of injectable valium in intravenous solutions. Anesthesia Progress, 25(5), 158-160.