Abstract
A study of the solubility of valium in commonly used intraveous solutions showed valium to be equally insoluble in 5% dextrose in normal saline, 5% dextrose in water, normal saline, and Ringer's lactate. However, the precipitate which was formed became completely resuspended when mixed with as little as 39-42% plasma in vitro. This would indicate that the chalky precipitate seen in the i.v. tubing when valium is injected into a running i.v. near the venipuncture site becomes resuspended when mixed with plasma in vivo. If one elects to inject valium into the tubing of a running i.v., it is recommended that the drug be administered slowly to assure adequate mixing with blood plasma in order to prevent the circulation of particulate matter.
Original language | English (US) |
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Pages (from-to) | 158-160 |
Number of pages | 3 |
Journal | Anesthesia Progress |
Volume | 25 |
Issue number | 5 |
State | Published - 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine