A study of the solubility of valium in commonly used intraveous solutions showed valium to be equally insoluble in 5% dextrose in normal saline, 5% dextrose in water, normal saline, and Ringer's lactate. However, the precipitate which was formed became completely resuspended when mixed with as little as 39-42% plasma in vitro. This would indicate that the chalky precipitate seen in the i.v. tubing when valium is injected into a running i.v. near the venipuncture site becomes resuspended when mixed with plasma in vivo. If one elects to inject valium into the tubing of a running i.v., it is recommended that the drug be administered slowly to assure adequate mixing with blood plasma in order to prevent the circulation of particulate matter.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Dec 1 1978|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine