Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]

M. A.M. Ali, P. Pinkerton, S. W.S. Chow, S. D. Zaetz, J. B. Wilson, B. B. Webber, H. Hu, Ferdane Kutlar, T. H.J. Huisman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A few rare hemoglobin variants with altered functional properties have been observed in Canadian subjects with either an erythrocytosis or mild anemia. These variants were Hb Alberta [β101(G3)Glu→Gly], Hb Linkoping [β36(C2)Pro→Thr], a new variant Hb Sunnybrook [β36(CE)Pro→Arg], and Hb Caribbean [β91(F7)Leu→Arg]. Short clinical descriptions of the subjects are given, the characterization of the variants is described in detail (except for Hb Alberta), while data from some functional analyses are provided. Comparisons with previously published data have been made and the unusual chromatographic property of two abnormal β chains in a reversed phase high performance liquid chromatographic system is reviewed.

Original languageEnglish (US)
Pages (from-to)137-148
Number of pages12
JournalHemoglobin
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1988

Fingerprint

Hemoglobins
Oxygen
Polycythemia
Anemia
Liquids
hemoglobin Sunnybrook
hemoglobin Linkoeping
hemoglobin Caribbean
hemoglobin Alberta

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]. / Ali, M. A.M.; Pinkerton, P.; Chow, S. W.S.; Zaetz, S. D.; Wilson, J. B.; Webber, B. B.; Hu, H.; Kutlar, Ferdane; Huisman, T. H.J.

In: Hemoglobin, Vol. 12, No. 2, 01.01.1988, p. 137-148.

Research output: Contribution to journalArticle

Ali, M. A.M. ; Pinkerton, P. ; Chow, S. W.S. ; Zaetz, S. D. ; Wilson, J. B. ; Webber, B. B. ; Hu, H. ; Kutlar, Ferdane ; Huisman, T. H.J. / Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]. In: Hemoglobin. 1988 ; Vol. 12, No. 2. pp. 137-148.
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