Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]

M. A.M. Ali; P. Pinkerton; S. W.S. Chow; S. D. Zaetz; J. B. Wilson; B. B. Webber; H. Hu; F. Kutlar; T. H.J. Huisman

doi:10.3109/03630268808998020

Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]

M. A.M. Ali, P. Pinkerton, S. W.S. Chow, S. D. Zaetz, J. B. Wilson, B. B. Webber, H. Hu, F. Kutlar, T. H.J. Huisman

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

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Abstract

A few rare hemoglobin variants with altered functional properties have been observed in Canadian subjects with either an erythrocytosis or mild anemia. These variants were Hb Alberta [β101(G3)Glu→Gly], Hb Linkoping [β36(C2)Pro→Thr], a new variant Hb Sunnybrook [β36(CE)Pro→Arg], and Hb Caribbean [β91(F7)Leu→Arg]. Short clinical descriptions of the subjects are given, the characterization of the variants is described in detail (except for Hb Alberta), while data from some functional analyses are provided. Comparisons with previously published data have been made and the unusual chromatographic property of two abnormal β chains in a reversed phase high performance liquid chromatographic system is reviewed.

Original language	English (US)
Pages (from-to)	137-148
Number of pages	12
Journal	Hemoglobin
Volume	12
Issue number	2
DOIs	https://doi.org/10.3109/03630268808998020
State	Published - 1988

ASJC Scopus subject areas

Hematology
Genetics(clinical)
Clinical Biochemistry
Biochemistry, medical

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Ali, M. A. M., Pinkerton, P., Chow, S. W. S., Zaetz, S. D., Wilson, J. B., Webber, B. B., Hu, H., Kutlar, F., & Huisman, T. H. J. (1988). Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]. Hemoglobin, 12(2), 137-148. https://doi.org/10.3109/03630268808998020

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title = "Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]",

abstract = "A few rare hemoglobin variants with altered functional properties have been observed in Canadian subjects with either an erythrocytosis or mild anemia. These variants were Hb Alberta [β101(G3)Glu→Gly], Hb Linkoping [β36(C2)Pro→Thr], a new variant Hb Sunnybrook [β36(CE)Pro→Arg], and Hb Caribbean [β91(F7)Leu→Arg]. Short clinical descriptions of the subjects are given, the characterization of the variants is described in detail (except for Hb Alberta), while data from some functional analyses are provided. Comparisons with previously published data have been made and the unusual chromatographic property of two abnormal β chains in a reversed phase high performance liquid chromatographic system is reviewed.",

author = "Ali, {M. A.M.} and P. Pinkerton and Chow, {S. W.S.} and Zaetz, {S. D.} and Wilson, {J. B.} and Webber, {B. B.} and H. Hu and F. Kutlar and Huisman, {T. H.J.}",

note = "Funding Information: This research was supported by USPHS Research Grants HLB-05168 and HLB-15158 and by the St. Joseph's Hospital Foundation, Hamilton, Ontario. This is contribution #lo87 from the Department o f Cell and Molecular Biology at the Medical College of Georgia in Augusta, Georgia.",

year = "1988",

doi = "10.3109/03630268808998020",

language = "English (US)",

volume = "12",

pages = "137--148",

journal = "Hemoglobin",

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AU - Ali, M. A.M.

AU - Pinkerton, P.

AU - Chow, S. W.S.

AU - Zaetz, S. D.

AU - Wilson, J. B.

AU - Webber, B. B.

AU - Hu, H.

AU - Kutlar, F.

AU - Huisman, T. H.J.

N1 - Funding Information: This research was supported by USPHS Research Grants HLB-05168 and HLB-15158 and by the St. Joseph's Hospital Foundation, Hamilton, Ontario. This is contribution #lo87 from the Department o f Cell and Molecular Biology at the Medical College of Georgia in Augusta, Georgia.

PY - 1988

Y1 - 1988

N2 - A few rare hemoglobin variants with altered functional properties have been observed in Canadian subjects with either an erythrocytosis or mild anemia. These variants were Hb Alberta [β101(G3)Glu→Gly], Hb Linkoping [β36(C2)Pro→Thr], a new variant Hb Sunnybrook [β36(CE)Pro→Arg], and Hb Caribbean [β91(F7)Leu→Arg]. Short clinical descriptions of the subjects are given, the characterization of the variants is described in detail (except for Hb Alberta), while data from some functional analyses are provided. Comparisons with previously published data have been made and the unusual chromatographic property of two abnormal β chains in a reversed phase high performance liquid chromatographic system is reviewed.

AB - A few rare hemoglobin variants with altered functional properties have been observed in Canadian subjects with either an erythrocytosis or mild anemia. These variants were Hb Alberta [β101(G3)Glu→Gly], Hb Linkoping [β36(C2)Pro→Thr], a new variant Hb Sunnybrook [β36(CE)Pro→Arg], and Hb Caribbean [β91(F7)Leu→Arg]. Short clinical descriptions of the subjects are given, the characterization of the variants is described in detail (except for Hb Alberta), while data from some functional analyses are provided. Comparisons with previously published data have been made and the unusual chromatographic property of two abnormal β chains in a reversed phase high performance liquid chromatographic system is reviewed.

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Some rare hemoglobin variants with altered oxygen affinities; hb linkoping [β36(c2)pro→thr], hb caribbean [β91(f7)leu→ar6], and hb sunnybrook [β 36(c2)pro→arg]

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