Space-providing expanded polytetrafluoroethylene devices define alveolar augmentation at dental implants induced by recombinant human bone morphogenetic protein 2 in an absorbable collagen sponge carrier

Ulf M E Wikesjö, Mohammed Qahash, Robert C. Thomson, Alonzo D. Cook, Michael D. Rohrer, John M. Wozney, W. Ross Hardwick

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: Surgical implantation of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) significantly enhances bone regeneration in horizontal alveolar defects; however, sufficient quantities of bone for implant dentistry are not routinely obtained. Purpose: The objective of this proof-of-principle study was to evaluate the potential of a space-providing macroporous expanded polytetrafluoroethylene (ePTFE) device to control volume and geometry of rhBMP-2/ACS-induced alveolar bone augmentation. Materials and Methods: Bilateral critical-size supra-alveolar periimplant defects were created in four Hound-Labrador mongrel dogs. Two turned and one surface-etched 10 mm titanium dental implants were placed 5 mm into the surgically reduced alveolar ridge creating 5 mm supra-alveolar defects, rhBMP-2/ACS (0.4 mg rhBMP-2) was placed around the exposed dental implants. Additionally, one jaw quadrant in each animal was randomly assigned to receive the dome-shaped macroporous ePTFE device. Mucoperiosteal flaps were advanced for primary wound closure. The animals were euthanized at 8 weeks post surgery for histometric analysis. Results: The space-providing macroporous ePTFE device defined the volume and geometry of rhBMP-2/ACS-induced bone formation, whereas bone formation at sites receiving rhBMP-2/ACS alone varied considerably. Vertical bone gain at turned dental implants averaged (± SD) 4.7 ± 0.2 mm at sites receiving rhBMP-2/ACS and the ePTFE device compared with 3.5 ± 0.9 mm at sites receiving rhBMP-2/ACS only. The corresponding values for rhBMP-2/ACS-induced bone area were 9.6 ± 0.7 mm2 and 7.5 ± 6.2 mm 2. There was a highly significant correlation between induced bone area and the space provided by the ePTFE device (p < .001). There was no difference in induced bone density or bone-implant contact between the two technologies. These observations were consistent with those observed at surface-etched dental implants. Conclusions: The data from this study suggest that a space-providing macroporous ePTFE device defines rhBMP-2/ACS-induced alveolar augmentation to provide adequate bone quantities for implant dentistry. The dental implant surface technology does not appear to substantially influence bone formation.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalClinical Implant Dentistry and Related Research
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2003

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Dental Implants
Polytetrafluoroethylene
Porifera
Collagen
Equipment and Supplies
Bone and Bones
Osteogenesis
Dentistry
recombinant human bone morphogenetic protein-2
Technology
Newfoundland and Labrador
Alveolar Process
Bone Regeneration
Titanium
Jaw
Bone Density
Dogs

Keywords

  • Differentiation factors
  • Regeneration
  • Seroma
  • Tissue engineering
  • Wound healing

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry(all)

Cite this

Space-providing expanded polytetrafluoroethylene devices define alveolar augmentation at dental implants induced by recombinant human bone morphogenetic protein 2 in an absorbable collagen sponge carrier. / Wikesjö, Ulf M E; Qahash, Mohammed; Thomson, Robert C.; Cook, Alonzo D.; Rohrer, Michael D.; Wozney, John M.; Hardwick, W. Ross.

In: Clinical Implant Dentistry and Related Research, Vol. 5, No. 2, 01.01.2003, p. 112-123.

Research output: Contribution to journalArticle

Wikesjö, Ulf M E ; Qahash, Mohammed ; Thomson, Robert C. ; Cook, Alonzo D. ; Rohrer, Michael D. ; Wozney, John M. ; Hardwick, W. Ross. / Space-providing expanded polytetrafluoroethylene devices define alveolar augmentation at dental implants induced by recombinant human bone morphogenetic protein 2 in an absorbable collagen sponge carrier. In: Clinical Implant Dentistry and Related Research. 2003 ; Vol. 5, No. 2. pp. 112-123.
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abstract = "Background: Surgical implantation of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) significantly enhances bone regeneration in horizontal alveolar defects; however, sufficient quantities of bone for implant dentistry are not routinely obtained. Purpose: The objective of this proof-of-principle study was to evaluate the potential of a space-providing macroporous expanded polytetrafluoroethylene (ePTFE) device to control volume and geometry of rhBMP-2/ACS-induced alveolar bone augmentation. Materials and Methods: Bilateral critical-size supra-alveolar periimplant defects were created in four Hound-Labrador mongrel dogs. Two turned and one surface-etched 10 mm titanium dental implants were placed 5 mm into the surgically reduced alveolar ridge creating 5 mm supra-alveolar defects, rhBMP-2/ACS (0.4 mg rhBMP-2) was placed around the exposed dental implants. Additionally, one jaw quadrant in each animal was randomly assigned to receive the dome-shaped macroporous ePTFE device. Mucoperiosteal flaps were advanced for primary wound closure. The animals were euthanized at 8 weeks post surgery for histometric analysis. Results: The space-providing macroporous ePTFE device defined the volume and geometry of rhBMP-2/ACS-induced bone formation, whereas bone formation at sites receiving rhBMP-2/ACS alone varied considerably. Vertical bone gain at turned dental implants averaged (± SD) 4.7 ± 0.2 mm at sites receiving rhBMP-2/ACS and the ePTFE device compared with 3.5 ± 0.9 mm at sites receiving rhBMP-2/ACS only. The corresponding values for rhBMP-2/ACS-induced bone area were 9.6 ± 0.7 mm2 and 7.5 ± 6.2 mm 2. There was a highly significant correlation between induced bone area and the space provided by the ePTFE device (p < .001). There was no difference in induced bone density or bone-implant contact between the two technologies. These observations were consistent with those observed at surface-etched dental implants. Conclusions: The data from this study suggest that a space-providing macroporous ePTFE device defines rhBMP-2/ACS-induced alveolar augmentation to provide adequate bone quantities for implant dentistry. The dental implant surface technology does not appear to substantially influence bone formation.",
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AU - Wikesjö, Ulf M E

AU - Qahash, Mohammed

AU - Thomson, Robert C.

AU - Cook, Alonzo D.

AU - Rohrer, Michael D.

AU - Wozney, John M.

AU - Hardwick, W. Ross

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