Spatially dependent activation of the patterning protease, Easter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The dorsoventral axis of the Drosophila embryo is established by the activating cleavage of a signaling ligand by a serine protease, Easter, only on the ventral side of the embryo. Easter is the final protease in a serine protease cascade in which initial reaction steps appear not to be ventrally restricted, but where Easter activity is promoted ventrally through the action of a spatial cue at an unknown step in the pathway. Here, biochemical studies demonstrate that this spatial control occurs at or above the level of Easter zymogen activation, rather than through direct promotion of Easter's catalytic activity against the signaling ligand.

Original languageEnglish (US)
Pages (from-to)2269-2272
Number of pages4
JournalFEBS Letters
Volume580
Issue number9
DOIs
StatePublished - Apr 17 2006

Fingerprint

Serine Proteases
Peptide Hydrolases
Embryonic Structures
Chemical activation
Ligands
Enzyme Precursors
Drosophila
Cues
Catalyst activity

Keywords

  • Drosophila
  • Easter
  • Serine protease
  • Zymogen activation
  • pipe

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Spatially dependent activation of the patterning protease, Easter. / LeMosy, Ellen.

In: FEBS Letters, Vol. 580, No. 9, 17.04.2006, p. 2269-2272.

Research output: Contribution to journalArticle

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