Species difference in the modulatory effect of κ agonist on 5-HT release from ground squirrel and rat hippocampus

Yan Cui, Tze fun Lee, Lawrence C.H. Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Inclusion of the κ agonist U50488 in the perifusion medium enhanced K+-stimulated 5-HT release from ground squirrel hippocampal slices, but reduced 5-HT outflow in both young and old rats' hippocampal slices. The stimulatory effect of U50488 on 5-HT release from ground squirrel hippocampus was not significantly attenuated by the non-specific opioid antagonist naloxone (10-5 M), but was completely reversed by the specific κ antagonist nor-BNI (10-6 M), and the voltage-dependent sodium channel blocker TTX (10-6 M). In contrast, the inhibitory effect of U50488 on 5-HT release from the young rat hippocampus was attenuated by naloxone (10-6 M), but not by nor-BNI (10-6 M) or TTX (10-6 M). These results illustrate a significant species difference in the modulatory effect of opioids on neurotransmitter release in the hippocampus.

Original languageEnglish (US)
Pages (from-to)126-128
Number of pages3
JournalNeuroscience Letters
Volume175
Issue number1-2
DOIs
StatePublished - Jul 4 1994
Externally publishedYes

Keywords

  • Hippocampus
  • Opioid
  • Serotonin release
  • U50488
  • κ Opioid receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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