Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia

R. Yarchoan, H. S. Schneider, Betty Beasley Wray, D. L. Nelson

Research output: Contribution to journalArticle

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Abstract

Specific anti-influenza virus antibody production in vitro was studied in peripheral blood mononuclear cells from 17 patients with hypogammaglobulinemia. Cells obtained from 6 of 12 patients with common variable hypogammaglobulinemia produced anti-influenza virus antibody, predominantly of the IgM isotype, when cultured in vitro with type A influenza virus. No antibody was produced in vitro, however, by cells from either of two patients with Bruton's type X-linked hypogammaglobulinemia or by cells from any of three patients with X-linked hypogammaglobulinemia and isolated growth hormone deficiency. These studies demonstrate that peripheral blood mononuclear cells from a subset of patients with common variable hypogammaglobulinemia retain the potential to produce specific antibody in response to antigenic stimulation.

Original languageEnglish (US)
Pages (from-to)1720-1727
Number of pages8
JournalJournal of Clinical Investigation
Volume71
Issue number6
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Agammaglobulinemia
Lymphocyte Subsets
Orthomyxoviridae
Antibody Formation
Common Variable Immunodeficiency
Blood Cells
Antibodies
Influenza A virus
Immunoglobulin M
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

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Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia. / Yarchoan, R.; Schneider, H. S.; Wray, Betty Beasley; Nelson, D. L.

In: Journal of Clinical Investigation, Vol. 71, No. 6, 01.01.1983, p. 1720-1727.

Research output: Contribution to journalArticle

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