Specific genetic influences on nighttime blood pressure

Xiaojing Xu, Shaoyong Su, Frank A. Treiber, Robert Vlietinck, Robert Fagard, Catherine Derom, Marij Gielen, Ruth J.F. Loos, Harold Snieder, Xiaoling Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVES: Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and 67% of the nighttime systolic BP (SBP) and diastolic BP (DBP) heritabilities, respectively. Here, we determined whether these results could be confirmed in a much larger twin cohort of young adults with 24-hour ambulatory BP measurements. METHODS: Ambulatory BP was available in 703 white twins (308 pairs and 87 singletons, aged 18-34 years, 50% males) from the Prenatal Programming Twin Study. A bivariate quantitative genetic twin model was used to analyze daytime and nighttime BP. We conducted a meta-analysis to compare and integrate results from the 2 twin cohorts. RESULTS: Model fitting showed no sex differences for any of the measures. Heritabilities were 0.60 and 0.51 for SBP and 0.54 and 0.46 for DBP at daytime and nighttime. The specific heritability due to novel genetic effects emerging during the nighttime was 0.21 for SBP and 0.26 for DBP, which comprised 41% and 57% of the total nighttime heritability for SBP and DBP, respectively. Meta-analysis confirmed absence of cohort differences with very similar combined results. CONCLUSIONS In addition to genes that influence both daytime and nighttime BP, a large part of the heritability is explained by genes that specifically influence BP at night.

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
JournalAmerican journal of hypertension
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Blood Pressure
Twin Studies
Meta-Analysis
Embryonic and Fetal Development
Genes
Genetic Models
Sex Characteristics
Young Adult
Hypertension
Mortality

Keywords

  • Heritability
  • Meta-analysis
  • Nighttime blood pressure
  • Twin study

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Specific genetic influences on nighttime blood pressure. / Xu, Xiaojing; Su, Shaoyong; Treiber, Frank A.; Vlietinck, Robert; Fagard, Robert; Derom, Catherine; Gielen, Marij; Loos, Ruth J.F.; Snieder, Harold; Wang, Xiaoling.

In: American journal of hypertension, Vol. 28, No. 4, 01.04.2015, p. 440-443.

Research output: Contribution to journalArticle

Xu, X, Su, S, Treiber, FA, Vlietinck, R, Fagard, R, Derom, C, Gielen, M, Loos, RJF, Snieder, H & Wang, X 2015, 'Specific genetic influences on nighttime blood pressure', American journal of hypertension, vol. 28, no. 4, pp. 440-443. https://doi.org/10.1093/ajh/hpu162
Xu X, Su S, Treiber FA, Vlietinck R, Fagard R, Derom C et al. Specific genetic influences on nighttime blood pressure. American journal of hypertension. 2015 Apr 1;28(4):440-443. https://doi.org/10.1093/ajh/hpu162
Xu, Xiaojing ; Su, Shaoyong ; Treiber, Frank A. ; Vlietinck, Robert ; Fagard, Robert ; Derom, Catherine ; Gielen, Marij ; Loos, Ruth J.F. ; Snieder, Harold ; Wang, Xiaoling. / Specific genetic influences on nighttime blood pressure. In: American journal of hypertension. 2015 ; Vol. 28, No. 4. pp. 440-443.
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abstract = "OBJECTIVES: Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44{\%} and 67{\%} of the nighttime systolic BP (SBP) and diastolic BP (DBP) heritabilities, respectively. Here, we determined whether these results could be confirmed in a much larger twin cohort of young adults with 24-hour ambulatory BP measurements. METHODS: Ambulatory BP was available in 703 white twins (308 pairs and 87 singletons, aged 18-34 years, 50{\%} males) from the Prenatal Programming Twin Study. A bivariate quantitative genetic twin model was used to analyze daytime and nighttime BP. We conducted a meta-analysis to compare and integrate results from the 2 twin cohorts. RESULTS: Model fitting showed no sex differences for any of the measures. Heritabilities were 0.60 and 0.51 for SBP and 0.54 and 0.46 for DBP at daytime and nighttime. The specific heritability due to novel genetic effects emerging during the nighttime was 0.21 for SBP and 0.26 for DBP, which comprised 41{\%} and 57{\%} of the total nighttime heritability for SBP and DBP, respectively. Meta-analysis confirmed absence of cohort differences with very similar combined results. CONCLUSIONS In addition to genes that influence both daytime and nighttime BP, a large part of the heritability is explained by genes that specifically influence BP at night.",
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AU - Su, Shaoyong

AU - Treiber, Frank A.

AU - Vlietinck, Robert

AU - Fagard, Robert

AU - Derom, Catherine

AU - Gielen, Marij

AU - Loos, Ruth J.F.

AU - Snieder, Harold

AU - Wang, Xiaoling

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N2 - OBJECTIVES: Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and 67% of the nighttime systolic BP (SBP) and diastolic BP (DBP) heritabilities, respectively. Here, we determined whether these results could be confirmed in a much larger twin cohort of young adults with 24-hour ambulatory BP measurements. METHODS: Ambulatory BP was available in 703 white twins (308 pairs and 87 singletons, aged 18-34 years, 50% males) from the Prenatal Programming Twin Study. A bivariate quantitative genetic twin model was used to analyze daytime and nighttime BP. We conducted a meta-analysis to compare and integrate results from the 2 twin cohorts. RESULTS: Model fitting showed no sex differences for any of the measures. Heritabilities were 0.60 and 0.51 for SBP and 0.54 and 0.46 for DBP at daytime and nighttime. The specific heritability due to novel genetic effects emerging during the nighttime was 0.21 for SBP and 0.26 for DBP, which comprised 41% and 57% of the total nighttime heritability for SBP and DBP, respectively. Meta-analysis confirmed absence of cohort differences with very similar combined results. CONCLUSIONS In addition to genes that influence both daytime and nighttime BP, a large part of the heritability is explained by genes that specifically influence BP at night.

AB - OBJECTIVES: Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and 67% of the nighttime systolic BP (SBP) and diastolic BP (DBP) heritabilities, respectively. Here, we determined whether these results could be confirmed in a much larger twin cohort of young adults with 24-hour ambulatory BP measurements. METHODS: Ambulatory BP was available in 703 white twins (308 pairs and 87 singletons, aged 18-34 years, 50% males) from the Prenatal Programming Twin Study. A bivariate quantitative genetic twin model was used to analyze daytime and nighttime BP. We conducted a meta-analysis to compare and integrate results from the 2 twin cohorts. RESULTS: Model fitting showed no sex differences for any of the measures. Heritabilities were 0.60 and 0.51 for SBP and 0.54 and 0.46 for DBP at daytime and nighttime. The specific heritability due to novel genetic effects emerging during the nighttime was 0.21 for SBP and 0.26 for DBP, which comprised 41% and 57% of the total nighttime heritability for SBP and DBP, respectively. Meta-analysis confirmed absence of cohort differences with very similar combined results. CONCLUSIONS In addition to genes that influence both daytime and nighttime BP, a large part of the heritability is explained by genes that specifically influence BP at night.

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