Spectrophotometric method for the determination of nifedipine with 4-(methylamino)phenol and potassium dichromate

Nafisur Rahman, Md Nasrul Hoda

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A new simple, sensitive and reproducible spectrophotometric method for the determination of nifedipine in pure and dosage forms has been proposed. It is based on the reduction of nifedipine with Zn/NH4Cl, followed by coupling with N-methyl-1,4-benzoquinoneimine - the oxidation product of 4-(methylamino)phenol, to give a chromophore which absorbed maximally at 525 nm. The experimental conditions were optimised and Beer's law was obeyed over the concentration range of 5-175 μg ml-1. The molar absorptivity, detection limit, recovery and RSD were found to be 1.9×103 l mol-1 cm-1, 1.1 μg ml-1, 99.7-100.5% and 0.3-0.8%, respectively. The proposed method was compared favourably with the official B.P. method.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalFarmaco
Volume57
Issue number6
DOIs
StatePublished - May 22 2002

Keywords

  • 4-(Methylamino)phenol
  • N-Methyl-1,4-benzoquinoneimine
  • Nifedipine
  • Potassium dichromate
  • Visible spectrophotometry

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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