Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Siva S. Panda; Adel S. Girgis; Marian N. Aziz; Mohamed S. Bekheit

doi:10.3390/molecules28020618

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Siva S. Panda, Adel S. Girgis, Marian N. Aziz, Mohamed S. Bekheit

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

Original language	English (US)
Article number	618
Journal	Molecules
Volume	28
Issue number	2
DOIs	https://doi.org/10.3390/molecules28020618
State	Published - Jan 2023

Keywords

alkaloids
biological properties
natural product
spirooxindole
synthesis

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules28020618

Cite this

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title = "Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold",

abstract = "Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.",

keywords = "alkaloids, biological properties, natural product, spirooxindole, synthesis",

author = "Panda, {Siva S.} and Girgis, {Adel S.} and Aziz, {Marian N.} and Bekheit, {Mohamed S.}",

note = "Funding Information: We thank the Augusta University Provost{\textquoteright}s office, the Translational Research Program of the Department of Medicine, the Medical College of Georgia at Augusta University. This work was supported financially by National Research Centre, Egypt, project ID: 12060101. Publisher Copyright: {\textcopyright} 2023 by the authors.",

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language = "English (US)",

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journal = "Molecules",

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T1 - Spirooxindole

T2 - A Versatile Biologically Active Heterocyclic Scaffold

AU - Panda, Siva S.

AU - Girgis, Adel S.

AU - Aziz, Marian N.

AU - Bekheit, Mohamed S.

N1 - Funding Information: We thank the Augusta University Provost’s office, the Translational Research Program of the Department of Medicine, the Medical College of Georgia at Augusta University. This work was supported financially by National Research Centre, Egypt, project ID: 12060101. Publisher Copyright: © 2023 by the authors.

PY - 2023/1

Y1 - 2023/1

N2 - Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

AB - Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

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KW - biological properties

KW - natural product

KW - spirooxindole

KW - synthesis

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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Abstract

Keywords

ASJC Scopus subject areas

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