Spirooxindoles as potential pharmacophores

Siva S. Panda, Rachel A. Jones, Praveen Bachawala, Prabhu P. Mohapatra

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Original languageEnglish (US)
Pages (from-to)1515-1536
Number of pages22
JournalMini-Reviews in Medicinal Chemistry
Volume17
Issue number16
DOIs
StatePublished - Jan 1 2017

Keywords

  • Biological importance
  • Chemistry
  • Heterocycles
  • Pharmacophores
  • Spirooxindoles
  • Synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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