Spleen in sickle cell anemia

Comparative studies of Nigerian and U.S. patients

A. D. Adekile, K. M. McKie, O. O. Adeodu, A. J. Sulzer, J. ‐S Liu, V. C. McKie, Ferdane Kutlar, M. Ramachandran, W. Kaine, G. I. Akenzua, A. A. Okolo, A. A. Asindi, E. A. Obinyan, W. N. Ogala, M. Ibrahim, T. H.J. Huisman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age‐ and sex‐matched Nigerian and U.S. steady‐state SS patients were compared. Splenomegaly was found in 22.3% of Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean ± SE of IgG‐specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 ± 2,036; 9,334 ± 2,980 in those with spleens between 1 and 5 cm, 16,201 ± 4,502 in those with spleens between 6 and 10 cm, and 22,445 ± 8,456 in those with spleens above 10 cm. Coexistent α‐thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalAmerican Journal of Hematology
Volume42
Issue number3
DOIs
StatePublished - Jan 1 1993

Fingerprint

Sickle Cell Anemia
Spleen
Splenomegaly
Malaria
Complement C4
Complement C3
Thalassemia
Antibodies
Serum
Immunoglobulins

Keywords

  • African SS patients
  • SS
  • malaria
  • splenomegaly

ASJC Scopus subject areas

  • Hematology

Cite this

Adekile, A. D., McKie, K. M., Adeodu, O. O., Sulzer, A. J., Liu, J. S., McKie, V. C., ... Huisman, T. H. J. (1993). Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients. American Journal of Hematology, 42(3), 316-321. https://doi.org/10.1002/ajh.2830420313

Spleen in sickle cell anemia : Comparative studies of Nigerian and U.S. patients. / Adekile, A. D.; McKie, K. M.; Adeodu, O. O.; Sulzer, A. J.; Liu, J. ‐S; McKie, V. C.; Kutlar, Ferdane; Ramachandran, M.; Kaine, W.; Akenzua, G. I.; Okolo, A. A.; Asindi, A. A.; Obinyan, E. A.; Ogala, W. N.; Ibrahim, M.; Huisman, T. H.J.

In: American Journal of Hematology, Vol. 42, No. 3, 01.01.1993, p. 316-321.

Research output: Contribution to journalArticle

Adekile, AD, McKie, KM, Adeodu, OO, Sulzer, AJ, Liu, JS, McKie, VC, Kutlar, F, Ramachandran, M, Kaine, W, Akenzua, GI, Okolo, AA, Asindi, AA, Obinyan, EA, Ogala, WN, Ibrahim, M & Huisman, THJ 1993, 'Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients', American Journal of Hematology, vol. 42, no. 3, pp. 316-321. https://doi.org/10.1002/ajh.2830420313
Adekile AD, McKie KM, Adeodu OO, Sulzer AJ, Liu JS, McKie VC et al. Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients. American Journal of Hematology. 1993 Jan 1;42(3):316-321. https://doi.org/10.1002/ajh.2830420313
Adekile, A. D. ; McKie, K. M. ; Adeodu, O. O. ; Sulzer, A. J. ; Liu, J. ‐S ; McKie, V. C. ; Kutlar, Ferdane ; Ramachandran, M. ; Kaine, W. ; Akenzua, G. I. ; Okolo, A. A. ; Asindi, A. A. ; Obinyan, E. A. ; Ogala, W. N. ; Ibrahim, M. ; Huisman, T. H.J. / Spleen in sickle cell anemia : Comparative studies of Nigerian and U.S. patients. In: American Journal of Hematology. 1993 ; Vol. 42, No. 3. pp. 316-321.
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