Sporadic inclusion body myositis: Counts of different types of abnormal fibers

J. Ned Pruitt, Carol J. Showalter, Andrew G. Engel

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Invasion of nonnecrotic muscle fibers by cytotoxic T cells, accumulation of congophilic amyloid inclusions in muscle fibers, and fiber necrosis are consistent histologic findings in sporadic inclusion body myositis (IBM). To evaluate the relative significance of these alterations, we quantitatively analyzed the frequency of these abnormalities in 31 electron microscopy proven cases of IBM (20 untreated and 11 immunosuppressed). Nonnecrotic muscle fibers invaded by T cells were severalfold more frequent than fibers displaying the other pathologic alterations. Comparison of muscle samples from treated and untreated patients revealed no significant differences in the respective frequencies of the three species of abnormal fibers. Moreover, there was no correlation of the frequency of any abnormality either with disease duration or length of treatment. The much higher frequency of the invaded than Congo red-positive fibers points to the importance of an immune- mediated mechanism in the disease; but the basic cause of the disease remains undefined.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalAnnals of Neurology
Volume39
Issue number1
DOIs
StatePublished - Feb 14 1996
Externally publishedYes

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Inclusion Body Myositis
Muscles
T-Lymphocytes
Congo Red
Amyloid
Electron Microscopy
Necrosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Sporadic inclusion body myositis : Counts of different types of abnormal fibers. / Ned Pruitt, J.; Showalter, Carol J.; Engel, Andrew G.

In: Annals of Neurology, Vol. 39, No. 1, 14.02.1996, p. 139-143.

Research output: Contribution to journalArticle

Ned Pruitt, J. ; Showalter, Carol J. ; Engel, Andrew G. / Sporadic inclusion body myositis : Counts of different types of abnormal fibers. In: Annals of Neurology. 1996 ; Vol. 39, No. 1. pp. 139-143.
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