Squamous cell carcinoma of the nasal cavity: A population-based analysis

Aykut A. Unsal, Pariket M. Dubal, Tapan D. Patel, Alejandro Vazquez, Soly Baredes, James K. Liu, Jean Anderson Eloy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives/Hypothesis Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population-based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes. Study Design Retrospective database analysis. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2004-2012) was queried for NCSCC cases. Data were analyzed with respect to various demographic and clinicopathologic factors. The results were further examined for regional and distant metastasis. Survival was analyzed using the Kaplan-Meier model. Results A total of 1,180 cases of NCSCC were identified in the SEER database between 2004 and 2012. The mean age at diagnosis was 65.8 years. American Joint Committee on Cancer stage was known in 1,050 cases, of which 53.4% were stage I, 13.3% were stage II, 10.2% were stage III, and 23.0% were stage IV. By tumor (T) stage classification, T1 was the most common (56.6%), followed by T4 (19.3%). Most cases had no nodal (N) involvement at diagnosis (90.8%). Cervical nodal involvement was present in 9.1% of cases, while distant metastasis was seen in 1.9%. Five-year disease-specific survival was 69.5% overall, 39.6% in cases with neck involvement and 0.0% for metastatic cases. Conclusions This study represents the only known population-based investigation of NCSCC. Metastasis to cervical nodes or distant sites, especially with T1 tumors, is rare. However, any cervical involvement or distant metastasis discovered on presentation is a poor prognostic indicator. Level of Evidence 4. Laryngoscope, 126:560-565, 2016

Original languageEnglish (US)
Pages (from-to)560-565
Number of pages6
JournalLaryngoscope
Volume126
Issue number3
DOIs
StatePublished - Mar 1 2016

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Nasal Cavity
Squamous Cell Carcinoma
Neoplasm Metastasis
Databases
Population
Neoplasms
Epidemiology
Laryngoscopes
Neck
Retrospective Studies
Demography

Keywords

  • SEER
  • Squamous cell carcinoma
  • metastasis
  • nasal cavity
  • population-based
  • sinonasal malignancies
  • sinonasal neoplasm

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Unsal, A. A., Dubal, P. M., Patel, T. D., Vazquez, A., Baredes, S., Liu, J. K., & Eloy, J. A. (2016). Squamous cell carcinoma of the nasal cavity: A population-based analysis. Laryngoscope, 126(3), 560-565. https://doi.org/10.1002/lary.25531

Squamous cell carcinoma of the nasal cavity : A population-based analysis. / Unsal, Aykut A.; Dubal, Pariket M.; Patel, Tapan D.; Vazquez, Alejandro; Baredes, Soly; Liu, James K.; Eloy, Jean Anderson.

In: Laryngoscope, Vol. 126, No. 3, 01.03.2016, p. 560-565.

Research output: Contribution to journalArticle

Unsal, AA, Dubal, PM, Patel, TD, Vazquez, A, Baredes, S, Liu, JK & Eloy, JA 2016, 'Squamous cell carcinoma of the nasal cavity: A population-based analysis', Laryngoscope, vol. 126, no. 3, pp. 560-565. https://doi.org/10.1002/lary.25531
Unsal AA, Dubal PM, Patel TD, Vazquez A, Baredes S, Liu JK et al. Squamous cell carcinoma of the nasal cavity: A population-based analysis. Laryngoscope. 2016 Mar 1;126(3):560-565. https://doi.org/10.1002/lary.25531
Unsal, Aykut A. ; Dubal, Pariket M. ; Patel, Tapan D. ; Vazquez, Alejandro ; Baredes, Soly ; Liu, James K. ; Eloy, Jean Anderson. / Squamous cell carcinoma of the nasal cavity : A population-based analysis. In: Laryngoscope. 2016 ; Vol. 126, No. 3. pp. 560-565.
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abstract = "Objectives/Hypothesis Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population-based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes. Study Design Retrospective database analysis. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2004-2012) was queried for NCSCC cases. Data were analyzed with respect to various demographic and clinicopathologic factors. The results were further examined for regional and distant metastasis. Survival was analyzed using the Kaplan-Meier model. Results A total of 1,180 cases of NCSCC were identified in the SEER database between 2004 and 2012. The mean age at diagnosis was 65.8 years. American Joint Committee on Cancer stage was known in 1,050 cases, of which 53.4{\%} were stage I, 13.3{\%} were stage II, 10.2{\%} were stage III, and 23.0{\%} were stage IV. By tumor (T) stage classification, T1 was the most common (56.6{\%}), followed by T4 (19.3{\%}). Most cases had no nodal (N) involvement at diagnosis (90.8{\%}). Cervical nodal involvement was present in 9.1{\%} of cases, while distant metastasis was seen in 1.9{\%}. Five-year disease-specific survival was 69.5{\%} overall, 39.6{\%} in cases with neck involvement and 0.0{\%} for metastatic cases. Conclusions This study represents the only known population-based investigation of NCSCC. Metastasis to cervical nodes or distant sites, especially with T1 tumors, is rare. However, any cervical involvement or distant metastasis discovered on presentation is a poor prognostic indicator. Level of Evidence 4. Laryngoscope, 126:560-565, 2016",
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N2 - Objectives/Hypothesis Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population-based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes. Study Design Retrospective database analysis. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2004-2012) was queried for NCSCC cases. Data were analyzed with respect to various demographic and clinicopathologic factors. The results were further examined for regional and distant metastasis. Survival was analyzed using the Kaplan-Meier model. Results A total of 1,180 cases of NCSCC were identified in the SEER database between 2004 and 2012. The mean age at diagnosis was 65.8 years. American Joint Committee on Cancer stage was known in 1,050 cases, of which 53.4% were stage I, 13.3% were stage II, 10.2% were stage III, and 23.0% were stage IV. By tumor (T) stage classification, T1 was the most common (56.6%), followed by T4 (19.3%). Most cases had no nodal (N) involvement at diagnosis (90.8%). Cervical nodal involvement was present in 9.1% of cases, while distant metastasis was seen in 1.9%. Five-year disease-specific survival was 69.5% overall, 39.6% in cases with neck involvement and 0.0% for metastatic cases. Conclusions This study represents the only known population-based investigation of NCSCC. Metastasis to cervical nodes or distant sites, especially with T1 tumors, is rare. However, any cervical involvement or distant metastasis discovered on presentation is a poor prognostic indicator. Level of Evidence 4. Laryngoscope, 126:560-565, 2016

AB - Objectives/Hypothesis Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population-based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes. Study Design Retrospective database analysis. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2004-2012) was queried for NCSCC cases. Data were analyzed with respect to various demographic and clinicopathologic factors. The results were further examined for regional and distant metastasis. Survival was analyzed using the Kaplan-Meier model. Results A total of 1,180 cases of NCSCC were identified in the SEER database between 2004 and 2012. The mean age at diagnosis was 65.8 years. American Joint Committee on Cancer stage was known in 1,050 cases, of which 53.4% were stage I, 13.3% were stage II, 10.2% were stage III, and 23.0% were stage IV. By tumor (T) stage classification, T1 was the most common (56.6%), followed by T4 (19.3%). Most cases had no nodal (N) involvement at diagnosis (90.8%). Cervical nodal involvement was present in 9.1% of cases, while distant metastasis was seen in 1.9%. Five-year disease-specific survival was 69.5% overall, 39.6% in cases with neck involvement and 0.0% for metastatic cases. Conclusions This study represents the only known population-based investigation of NCSCC. Metastasis to cervical nodes or distant sites, especially with T1 tumors, is rare. However, any cervical involvement or distant metastasis discovered on presentation is a poor prognostic indicator. Level of Evidence 4. Laryngoscope, 126:560-565, 2016

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