Standard chemoradiation versus intensity-modulated chemoradiation

A quality of life assessment in oropharyngeal cancer patients

Sarah E. Mowry, Christopher Tang, Ahmad Sadeghi, Marilene B. Wang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This study is based on the context that many patients with advanced oropharyngeal carcinoma are being treated with primary chemoradiation. The aims of this study are to identify differences in quality of life (QOL) between patients with advanced oropharyngeal cancer following traditional chemoradiation versus chemotherapy with intensity-modulated radiation therapy (CIMRT). This research is designed on a cohort study from an academic tertiary referral center. Fifty patients were identiWed from an institutional database of patients who had undergone primary chemotherapy and radiation (traditional or IMRT) for advanced oropharyngeal carcinoma. Patients responded via mail using the University of Washington quality of life instrument version 4. Statistical analysis of data was performed using Chi-square and Wilcoxon tests. The results comprise the responses of 17 CRT (57%) and 14 CIMRT (70%) patients. The patients completed the survey between 9 and 44 months following end of treatment. When adjusted for tumor stage and time since treatment, CIMRT patients reported improved appearance (p = 0.05), chewing (p = 0.02), and mood (p = 0.01). There was a trend toward significance for improved activity (p = 0.07), recreation (p = 0.07), and anxiety (p = 0.08). There were no differences between the two groups for saliva, taste, shoulder function, speech, and swallowing. But there was a trend for significance for improved overall QOL in patients who had undergone CIMRT (p = 0.06). In conclusion, CIMRT results in improved QOL for some domains but surprisingly not for swallowing or saliva. Patients undergoing CIMRT also report slightly better QOL overall when compared to patients receiving more traditional forms of radiation therapy.

Original languageEnglish (US)
Pages (from-to)1111-1116
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume267
Issue number7
DOIs
StatePublished - Jul 1 2010

Fingerprint

Oropharyngeal Neoplasms
Quality of Life
Radiotherapy
Drug Therapy
Deglutition
Saliva
Carcinoma
Recreation
Statistical Data Interpretation
Mastication
Postal Service
Chi-Square Distribution
Tertiary Care Centers
Cohort Studies
Anxiety

Keywords

  • Chemoradiation
  • IMRT
  • Oropharyngeal cancer
  • Quality of life

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Standard chemoradiation versus intensity-modulated chemoradiation : A quality of life assessment in oropharyngeal cancer patients. / Mowry, Sarah E.; Tang, Christopher; Sadeghi, Ahmad; Wang, Marilene B.

In: European Archives of Oto-Rhino-Laryngology, Vol. 267, No. 7, 01.07.2010, p. 1111-1116.

Research output: Contribution to journalArticle

Mowry, Sarah E. ; Tang, Christopher ; Sadeghi, Ahmad ; Wang, Marilene B. / Standard chemoradiation versus intensity-modulated chemoradiation : A quality of life assessment in oropharyngeal cancer patients. In: European Archives of Oto-Rhino-Laryngology. 2010 ; Vol. 267, No. 7. pp. 1111-1116.
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