Standardized flavonoid-rich Eugenia jambolana seed extract retards in vitro and in vivo LDL oxidation and expression of VCAM-1 and P-selectin in atherogenic rats

Ravirajsinh N. Jadeja, Menaka C. Thouaojam, Jayantha M. Sankhari, Mahendra Jain, Ranjitsinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The present inventory evaluates anti-atherogenic potential of flavonoid-rich Eugenia jambolana seed extract (EJSE) against in vitro low-density lipoprotein (LDL) oxidation, foam cell formation, and atherogenic (ATH) diet-induced experimental atherosclerosis in rats. EJSE was able to prevent in vitro LDL oxidation and oxidized LDL-induced macrophage foam cell formation. Also, EJSE supplementation to ATH rats significantly minimized increment in serum markers of LDL oxidation. The ex vivo oxidation indices were also minimized in LDL of EJSE-treated animals. Microscopic evaluation of thoracic aorta of ATH + EJSE rats recorded minimal evidence of atheromatous plaque formation, accumulation of lipid laden macrophages, calcium deposition, and expression of cell adhesion molecules (vascular cell adhesion molecule-1 and P-selectin). This is the first scientific report that demonstrates anti-atherogenic potential of EJSE and warrants further evaluation at clinical level.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalCardiovascular Toxicology
Volume12
Issue number1
DOIs
StatePublished - Mar 2012

Keywords

  • Eugenia jambolana
  • Flavonoids
  • LDL oxidation
  • Macrophages
  • P-selectin
  • VCAM-1

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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