Staphylococcal opsonization and anti-Staphylococcus aureus IgG subclass antibodies in patients with severe or recurrent S. aureus infections

Michele A. Monteil, Ann St C. Kaniuk, John R. Hobbs

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Opsonization of Staphylococcus aureus (Oxford strain) and specific IgG subclass antibodies against formalised staphylococci were meausred in plamas from 27 patients with significant S. aureus infections and 35 healty adults and 15 children. There were no statistically significant differences in the IgG2 and IgG4 levels between two groups and IgG3 was not detected, but the median plasma IgG1 level was significantly higher in patients with staphylococcal infections (P < 0.00003). The concentration of IgG2 anti-S. aureus antibodies was 25-47 times greater than that of IgG1. If plasmas were decomplemented, the raised IgG1 levels were associated with increased opsonophagocytosis by normal neutrophils (P < 0.0002).

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalFEMS Microbiology Letters
Volume64
Issue number5-6
DOIs
StatePublished - Dec 1990

Keywords

  • Human IgG
  • Opsonisation
  • Staphylococcal infection

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Staphylococcal opsonization and anti-Staphylococcus aureus IgG subclass antibodies in patients with severe or recurrent S. aureus infections'. Together they form a unique fingerprint.

  • Cite this