STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma

Yeung Ho, Sai Wah Tsao, Musheng Zeng, Vivian Wai Yan Lui

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Nasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries.

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalCancer Letters
Volume330
Issue number2
DOIs
StatePublished - Apr 28 2013
Externally publishedYes

Keywords

  • EBV
  • Head and neck cancers
  • Molecular targeting
  • Nasopharyngeal cancer
  • STAT3

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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