State of the art etch-and-rinse adhesives

David Henry Pashley, Franklin Chi Meng Tay, Lorenzo Breschi, Leo Tjäderhane, Ricardo M. Carvalho, Marcela Carrilho, Arzu Tezvergil-Mutluay

Research output: Contribution to journalArticle

489 Scopus citations

Abstract

Objectives: The aim of this study was to explore the therapeutic opportunities of each step of 3-step etch-and-rinse adhesives. Methods: Etch-and-rinse adhesive systems are the oldest of the multi-generation evolution of resin bonding systems. In the 3-step version, they involve acid-etching, priming and application of a separate adhesive. Each step can accomplish multiple goals. Acid-etching, using 32-37% phosphoric acid (pH 0.1-0.4) not only simultaneously etches enamel and dentin, but the low pH kills many residual bacteria. Results: Some etchants include anti-microbial compounds such as benzalkonium chloride that also inhibits matrix metalloproteinases (MMPs) in dentin. Primers are usually water and HEMA-rich solutions that ensure complete expansion of the collagen fibril meshwork and wet the collagen with hydrophilic monomers. However, water alone can re-expand dried dentin and can also serve as a vehicle for protease inhibitors or protein cross-linking agents that may increase the durability of resin-dentin bonds. In the future, ethanol or other water-free solvents may serve as dehydrating primers that may also contain antibacterial quaternary ammonium methacrylates to inhibit dentin MMPs and increase the durability of resin-dentin bonds. The complete evaporation of solvents is nearly impossible. Significance: Manufacturers may need to optimize solvent concentrations. Solvent-free adhesives can seal resin-dentin interfaces with hydrophobic resins that may also contain fluoride and antimicrobial compounds. Etch-and-rinse adhesives produce higher resin-dentin bonds that are more durable than most 1 and 2-step adhesives. Incorporation of protease inhibitors in etchants and/or cross-linking agents in primers may increase the durability of resin-dentin bonds. The therapeutic potential of etch-and-rinse adhesives has yet to be fully exploited.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalDental Materials
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Acid-etchants
  • Adhesives
  • Durability
  • MMPs
  • Primers

ASJC Scopus subject areas

  • Materials Science(all)
  • Dentistry(all)
  • Mechanics of Materials

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  • Cite this

    Pashley, D. H., Tay, F. C. M., Breschi, L., Tjäderhane, L., Carvalho, R. M., Carrilho, M., & Tezvergil-Mutluay, A. (2011). State of the art etch-and-rinse adhesives. Dental Materials, 27(1), 1-16. https://doi.org/10.1016/j.dental.2010.10.016