Statins, Diabetic Oxidative Stress and Vascular Tissue

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter summarizes the basic and clinical science supporting the role of oxidative stress pathways in linking hyperglycemia to diabetic vascular disease. In addition to exploring the etiology and consequences of various sources of oxidative stress in diabetes, this chapter will focus on hydroxymethyl-glutaryl coA reductase inhibitors (or 'statins') for their impact on oxidative stress in diabetes - especially in their effects independent of lowering plasma lipids. The interaction of statins on tissue oxidases and on nitric oxide synthase uncoupling will be considered. Finally, this chapter addresses the key clinical trials of statins that have been shown to influence the development or progression of diabetic vascular disease.

Original languageEnglish (US)
Title of host publicationDiabetes
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Pages183-190
Number of pages8
ISBN (Print)9780124058859
DOIs
StatePublished - Nov 1 2013

Keywords

  • Hyperlipidemia
  • Nitric oxide
  • Oxidative stress
  • Statin
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

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  • Cite this

    Murrow, J. R. (2013). Statins, Diabetic Oxidative Stress and Vascular Tissue. In Diabetes: Oxidative Stress and Dietary Antioxidants (pp. 183-190). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405885-9.00019-X