Statins, diabetic oxidative stress, and vascular tissue

Research output: Chapter in Book/Report/Conference proceedingChapter


Basic and clinical science supports the role of oxidative stress pathways in linking hyperglycemia to diabetic vascular disease. This chapter will focus on hydroxymethyl-glutaryl coA reductase inhibitors (or “statins”) for their impact on oxidative stress in diabetes-especially in their effects independent of lowering plasma lipids. The interaction of statins on tissue oxidases and on nitric oxide synthase uncoupling will be considered in both in vitro and in vivo settings. Finally, key clinical trials of statins impacting diabetic vascular disease will be reviewed.

Original languageEnglish (US)
Title of host publicationDiabetes
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
Number of pages9
ISBN (Electronic)9780128157763
StatePublished - Jan 1 2020


  • Hyperlipidemia
  • Nitric oxide
  • Oxidative stress
  • Statin
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)


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