Various varieties of stem cells and methods of their administration are proposed as therapeutic modalities for neonatal hypoxic–ischemic (HI) brain injury. The widespread use of stem cells for this purpose and others, despite the lack of strong clinical evidence for their efficacy in most clinical situations, makes it incumbent to review the pathophysiology of the clinical condition of neonatal HI brain injury, the preclinical data dealing with animal HI injury, and the available clinical studies.
|Original language||English (US)|
|Title of host publication||Cell Therapy for Brain Injury|
|Publisher||Springer International Publishing|
|Number of pages||14|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)