Stem cells and tooth regeneration

prospects for personalized dentistry

Mahmood S Mozaffari, Golnaz Emami, Hesam Khodadadi, Babak Baban

Research output: Contribution to journalReview article

Abstract

Over the last several decades, a wealth of information has become available regarding various sources of stem cells and their potential use for regenerative purposes. Given the intense debate regarding embryonic stem cells, much of the focus has centered around application of adult stem cells for regenerative engineering along with other relevant aspects including use of growth factors and scaffolding materials. The more recent discovery of tooth-derived stem cells has sparked much interest in their application to regenerative dentistry to treat and alleviate the most prevalent oral diseases—i.e., dental caries and periodontal diseases. Also exciting is the advent of induced pluripotent stem cells, which provides the means of using patient-derived somatic cells for their creation, and their eventual application for generation of the dental complex. Thus, evolving developments in the field of regenerative dentistry indicate the prospect of constructing “custom-made” tooth and supporting structures thereby fostering the realization of “personalized dentistry.” On the other hand, others have explored the possibility of augmenting endogenous regenerative capacity through utilization of small molecules to regulate molecular signaling mechanisms that mediate regeneration of tooth structure. This review is focused on these aspects of regenerative dentistry in view of their relevance to personalized dentistry.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalEPMA Journal
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2019

Fingerprint

Dentistry
Stem cells
Regeneration
Tooth
Stem Cells
Cell Engineering
Stomatognathic Diseases
Periodontium
Induced Pluripotent Stem Cells
Adult Stem Cells
Foster Home Care
Dental Caries
Periodontal Diseases
Embryonic Stem Cells
Intercellular Signaling Peptides and Proteins
Molecules

Keywords

  • Dentin/pulp complex
  • Molecular mechanisms
  • Personalized dentistry
  • Predictive preventive personalized medicine (PPPM)
  • Stem cells
  • Tissue repair
  • Tooth regeneration

ASJC Scopus subject areas

  • Drug Discovery
  • Health Policy
  • Biochemistry, medical

Cite this

Stem cells and tooth regeneration : prospects for personalized dentistry. / Mozaffari, Mahmood S; Emami, Golnaz; Khodadadi, Hesam; Baban, Babak.

In: EPMA Journal, Vol. 10, No. 1, 01.03.2019, p. 31-42.

Research output: Contribution to journalReview article

Mozaffari, Mahmood S ; Emami, Golnaz ; Khodadadi, Hesam ; Baban, Babak. / Stem cells and tooth regeneration : prospects for personalized dentistry. In: EPMA Journal. 2019 ; Vol. 10, No. 1. pp. 31-42.
@article{598039e45cff4d4991966300bcba1bf9,
title = "Stem cells and tooth regeneration: prospects for personalized dentistry",
abstract = "Over the last several decades, a wealth of information has become available regarding various sources of stem cells and their potential use for regenerative purposes. Given the intense debate regarding embryonic stem cells, much of the focus has centered around application of adult stem cells for regenerative engineering along with other relevant aspects including use of growth factors and scaffolding materials. The more recent discovery of tooth-derived stem cells has sparked much interest in their application to regenerative dentistry to treat and alleviate the most prevalent oral diseases—i.e., dental caries and periodontal diseases. Also exciting is the advent of induced pluripotent stem cells, which provides the means of using patient-derived somatic cells for their creation, and their eventual application for generation of the dental complex. Thus, evolving developments in the field of regenerative dentistry indicate the prospect of constructing “custom-made” tooth and supporting structures thereby fostering the realization of “personalized dentistry.” On the other hand, others have explored the possibility of augmenting endogenous regenerative capacity through utilization of small molecules to regulate molecular signaling mechanisms that mediate regeneration of tooth structure. This review is focused on these aspects of regenerative dentistry in view of their relevance to personalized dentistry.",
keywords = "Dentin/pulp complex, Molecular mechanisms, Personalized dentistry, Predictive preventive personalized medicine (PPPM), Stem cells, Tissue repair, Tooth regeneration",
author = "Mozaffari, {Mahmood S} and Golnaz Emami and Hesam Khodadadi and Babak Baban",
year = "2019",
month = "3",
day = "1",
doi = "10.1007/s13167-018-0156-4",
language = "English (US)",
volume = "10",
pages = "31--42",
journal = "The EPMA Journal",
issn = "1878-5077",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Stem cells and tooth regeneration

T2 - prospects for personalized dentistry

AU - Mozaffari, Mahmood S

AU - Emami, Golnaz

AU - Khodadadi, Hesam

AU - Baban, Babak

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Over the last several decades, a wealth of information has become available regarding various sources of stem cells and their potential use for regenerative purposes. Given the intense debate regarding embryonic stem cells, much of the focus has centered around application of adult stem cells for regenerative engineering along with other relevant aspects including use of growth factors and scaffolding materials. The more recent discovery of tooth-derived stem cells has sparked much interest in their application to regenerative dentistry to treat and alleviate the most prevalent oral diseases—i.e., dental caries and periodontal diseases. Also exciting is the advent of induced pluripotent stem cells, which provides the means of using patient-derived somatic cells for their creation, and their eventual application for generation of the dental complex. Thus, evolving developments in the field of regenerative dentistry indicate the prospect of constructing “custom-made” tooth and supporting structures thereby fostering the realization of “personalized dentistry.” On the other hand, others have explored the possibility of augmenting endogenous regenerative capacity through utilization of small molecules to regulate molecular signaling mechanisms that mediate regeneration of tooth structure. This review is focused on these aspects of regenerative dentistry in view of their relevance to personalized dentistry.

AB - Over the last several decades, a wealth of information has become available regarding various sources of stem cells and their potential use for regenerative purposes. Given the intense debate regarding embryonic stem cells, much of the focus has centered around application of adult stem cells for regenerative engineering along with other relevant aspects including use of growth factors and scaffolding materials. The more recent discovery of tooth-derived stem cells has sparked much interest in their application to regenerative dentistry to treat and alleviate the most prevalent oral diseases—i.e., dental caries and periodontal diseases. Also exciting is the advent of induced pluripotent stem cells, which provides the means of using patient-derived somatic cells for their creation, and their eventual application for generation of the dental complex. Thus, evolving developments in the field of regenerative dentistry indicate the prospect of constructing “custom-made” tooth and supporting structures thereby fostering the realization of “personalized dentistry.” On the other hand, others have explored the possibility of augmenting endogenous regenerative capacity through utilization of small molecules to regulate molecular signaling mechanisms that mediate regeneration of tooth structure. This review is focused on these aspects of regenerative dentistry in view of their relevance to personalized dentistry.

KW - Dentin/pulp complex

KW - Molecular mechanisms

KW - Personalized dentistry

KW - Predictive preventive personalized medicine (PPPM)

KW - Stem cells

KW - Tissue repair

KW - Tooth regeneration

UR - http://www.scopus.com/inward/record.url?scp=85063048303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063048303&partnerID=8YFLogxK

U2 - 10.1007/s13167-018-0156-4

DO - 10.1007/s13167-018-0156-4

M3 - Review article

VL - 10

SP - 31

EP - 42

JO - The EPMA Journal

JF - The EPMA Journal

SN - 1878-5077

IS - 1

ER -