Abstract
We report five of 38 patients with stiff person syndrome (SPS), who also had cerebellar disease, gait ataxia, dysarthria, and oculomotor dysfunction (SPS-Cer). Cerebellar manifestations either preceded SPS or occurred concurrently. Brain MRI was normal. The intrathecal production of glutamic acid decarboxylase antibodies was elevated. γ-Aminobutyric acid-enhancing drugs and immunotherapies improved only the stiffness. SPS-Cer is a distinct subset of SPS causing a more severe and complex clinical phenotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1068-1070 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 67 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1 2006 |
| Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology
Fingerprint Dive into the research topics of 'Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies'. Together they form a unique fingerprint.
Cite this
Rakocevic, G., Raju, R. P., Semino-Mora, C., & Dalakas, M. C. (2006). Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. Neurology, 67(6), 1068-1070. https://doi.org/10.1212/01.wnl.0000237558.83349.d0