Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies

Goran Rakocevic, Raghavan Pillai Raju, Cristina Semino-Mora, Marinos C. Dalakas

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We report five of 38 patients with stiff person syndrome (SPS), who also had cerebellar disease, gait ataxia, dysarthria, and oculomotor dysfunction (SPS-Cer). Cerebellar manifestations either preceded SPS or occurred concurrently. Brain MRI was normal. The intrathecal production of glutamic acid decarboxylase antibodies was elevated. γ-Aminobutyric acid-enhancing drugs and immunotherapies improved only the stiffness. SPS-Cer is a distinct subset of SPS causing a more severe and complex clinical phenotype.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
JournalNeurology
Volume67
Issue number6
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

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Stiff-Person Syndrome
Cerebellar Diseases
Anti-Idiotypic Antibodies
Gait Ataxia
Aminobutyrates
Dysarthria
Glutamate Decarboxylase
Immunotherapy
Phenotype
Antibodies
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. / Rakocevic, Goran; Raju, Raghavan Pillai; Semino-Mora, Cristina; Dalakas, Marinos C.

In: Neurology, Vol. 67, No. 6, 01.09.2006, p. 1068-1070.

Research output: Contribution to journalArticle

Rakocevic, Goran ; Raju, Raghavan Pillai ; Semino-Mora, Cristina ; Dalakas, Marinos C. / Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. In: Neurology. 2006 ; Vol. 67, No. 6. pp. 1068-1070.
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