STIM and Orai proteins: Players in sexual differences in hypertension-associated vascular dysfunction?

Fernanda R.C. Giachini, R. Clinton Webb, Rita C. Tostes

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sex-associated differences in hypertension have been observed repeatedly in epidemiological studies; however, the mechanisms conferring vascular protection to females are not totally elucidated. Sex-related differences in intracellular Ca2+ handling or, more specifically, in mechanisms that regulate Ca2+ entry into vascular smooth muscle cells have been identified as players in sex-related differences in hypertension-associated vascular dysfunction. Recently, new signalling components that regulate Ca2+ influx, in conditions of intracellular store depletion, were identified: STIM1 (stromal interaction molecule 1), which works as an intracellular Ca2+ sensor; and Orai1, which is a component of the CRAC (Ca2+ release-activated Ca2+) channels. Together, these proteins reconstitute store-operated Ca2+ channel function. Disturbances in STIM1/Orai1 signalling have been implicated in pathophysiological conditions, including hypertension. In the present article, we analyse evidence for sex-related differences in Ca2+ handling and propose a new hypothesis where sex-related differences in STIM/Orai signalling may contribute to hypertension-associated vascular differences between male and female subjects.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalClinical Science
Volume118
Issue number6
DOIs
StatePublished - Jan 6 2010

Fingerprint

Sex Characteristics
Blood Vessels
Hypertension
Proteins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Epidemiologic Studies
Stromal Interaction Molecule 1

Keywords

  • Hypertension
  • Orai
  • Sex difference
  • Stromal interaction molecule (STIM)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

STIM and Orai proteins : Players in sexual differences in hypertension-associated vascular dysfunction? / Giachini, Fernanda R.C.; Webb, R. Clinton; Tostes, Rita C.

In: Clinical Science, Vol. 118, No. 6, 06.01.2010, p. 391-396.

Research output: Contribution to journalArticle

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