STIM1/Orai1-mediated store-operated Ca 2+ entry: The tip of the iceberg

F. R. Giachini, V. V. Lima, J. L. Hannan, F. S. Carneiro, R. C. Webb, R. C. Tostes

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Highly efficient mechanisms regulate intracellular calcium (Ca 2+) levels. The recent discovery of new components linking intracellular Ca 2+ stores to plasma membrane Ca 2+ entry channels has brought new insight into the understanding of Ca 2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca 2+ sensor essential for Ca 2+ store depletion-triggered Ca 2+ influx. Orai1 was recognized as being an essential component for the Ca 2+ release-activated Ca 2+ (CRAC) channel. Together, these proteins participate in store-operated Ca 2+ channel function. Defective regulation of intracellular Ca 2+ is a hallmark of several diseases. In this review, we focus on Ca 2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/ Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.

Original languageEnglish (US)
Pages (from-to)1080-1087
Number of pages8
JournalBrazilian Journal of Medical and Biological Research
Volume44
Issue number11
DOIs
StatePublished - Nov 2011

Keywords

  • Ca influx
  • Ca release-activated Ca channel
  • Intracellular Ca store
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Biochemistry
  • Physiology
  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Cell Biology

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