STIM1/Orai1-mediated store-operated Ca2+ entry: The tip of the iceberg

F. R. Giachini, V. V. Lima, J. L. Hannan, F. S. Carneiro, R. C. Webb, R. C. Tostes

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/ Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.

Original languageEnglish (US)
Pages (from-to)1080-1087
Number of pages8
JournalBrazilian Journal of Medical and Biological Research
Issue number11
StatePublished - Nov 2011
Externally publishedYes


  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Biochemistry
  • Physiology
  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Cell Biology


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