Abstract
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/ Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
Original language | English (US) |
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Pages (from-to) | 1080-1087 |
Number of pages | 8 |
Journal | Brazilian Journal of Medical and Biological Research |
Volume | 44 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2011 |
Externally published | Yes |
Keywords
- Sarcoplasmic reticulum
ASJC Scopus subject areas
- Biophysics
- Neuroscience(all)
- Biochemistry
- Physiology
- Immunology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Cell Biology