Stimulation of the nucleus raphe medialis modifies basal synaptic transmission at the dentate gyrus, but not long-term potentiation or its reinforcement by stimulation of the basolateral amygdala

Jorge A. Bergado, Thomas Scherf, William Almaguer-Melian, Sabine Martina Frey, Jeffrey López, Julietta Uta Frey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Affective factors importantly interact with behavior and memory. Physiological mechanisms that underlie such interactions are objects of intensive studies. This involves the direct investigation of its relevance to understand learning and memory formation as well as the search for possibilities to treat memory disorders. The prolonged maintenance of long-term potentiation (LTP) - a cellular model for memory formation - is characterized by neuromodulatory, associative requirements. During the last years, we have delineated a neural system that may be responsible for affective-cognitive interactions at the cellular level. The stimulation of the basolateral amygdala (BLA), within an effective, associative time window, reinforces a normally transient, protein synthesis-independent early-LTP (less than 4-6 h) into a long-lasting, protein synthesis-dependent late-LTP in the dentate gyrus (DG) in freely moving rats (Frey et al., 2001 [12]). LTP reinforcement by stimulation of the BLA was mediated by cholinergic projection of the medial septum to the DG, and the noradrenergic projection from the locus coeruleus (Bergado et al., 2007 [2]). We were now interested to investigate a possible interaction of the nucleus raphe medialis (NRM) with DG-LTP. Although, NRM stimulation resulted in a depressing effect on basal synaptic transmission, we did not observe any interactions with early-LTP or with the BLA-DG LTP-reinforcement system.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalNeuroscience Letters
Volume464
Issue number3
DOIs
StatePublished - Oct 30 2009

Fingerprint

Raphe Nuclei
Long-Term Potentiation
Dentate Gyrus
Synaptic Transmission
Locus Coeruleus
Memory Disorders
Basolateral Nuclear Complex
Reinforcement (Psychology)
Cholinergic Agents
Proteins
Learning

Keywords

  • Basolateral amygdala
  • Freely moving rats
  • Hippocampal long-term potentiation
  • LTP reinforcement
  • Nucleus raphe medialis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stimulation of the nucleus raphe medialis modifies basal synaptic transmission at the dentate gyrus, but not long-term potentiation or its reinforcement by stimulation of the basolateral amygdala. / Bergado, Jorge A.; Scherf, Thomas; Almaguer-Melian, William; Frey, Sabine Martina; López, Jeffrey; Frey, Julietta Uta.

In: Neuroscience Letters, Vol. 464, No. 3, 30.10.2009, p. 179-183.

Research output: Contribution to journalArticle

Bergado, Jorge A. ; Scherf, Thomas ; Almaguer-Melian, William ; Frey, Sabine Martina ; López, Jeffrey ; Frey, Julietta Uta. / Stimulation of the nucleus raphe medialis modifies basal synaptic transmission at the dentate gyrus, but not long-term potentiation or its reinforcement by stimulation of the basolateral amygdala. In: Neuroscience Letters. 2009 ; Vol. 464, No. 3. pp. 179-183.
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