Stimulatory effects of starfish sapogenins (Asterias amurensis and Lethasterias nanimensis chelifera) on molluscan heart (Spisula sachalinensis)

Boris A Gorshkov, Irina I. Kapustina, Alla A. Kicha, Dmitry L. Aminin, Irina A. Gorshkova

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Sapogenins from the starfish Asterias amurensis and Lethasterias nanimensis chelifera, 5α-pregn-9(11)-ene-3β,6α-diol-20-one, 5α-cholest-9(11)-ene-3β,6α-diol-23-one, 5α-cholesta-9(11),24(25)-diene-3β,6α-diol-23-one, (20E)-5α-cholesta-9(11),20(22)-diene-3β,6α-diol-23-one and 24ξ-methyl-5α-cholesta-9(11),20(22)-diene-3β,6α-diol-23-one, stimulated the contractile force of the heart of the mollusk Spisula sachalinensis at concentration of 5x10-5 M. Ouabain, a specific inhibitor of Na+,K+-ATPase, at concentration of 5x10-5 M had no effect on this physiological model. Starfish sapogenins of the cholestane series moderately inhibited rat brain cortex Na+,K+-ATPase and decreased Ca2+ influx into Ehrlich carcinoma cells. In contrast, pregnane asterogenin asterone did not inhibit Na+,K+-ATPase and increased the influx of Ca2+ into cells. These effects were not the result of cell membrane damage, because none of the compounds tested have hemolytic activity. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalComparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volume120
Issue number2
DOIs
StatePublished - Aug 1 1998

Fingerprint

Spisula
Asterias
Sapogenins
Starfish
Cholestanes
Pregnanes
Mollusca
Ouabain
Cell Membrane
Carcinoma
Brain
sodium-translocating ATPase

Keywords

  • Asterias amurensis
  • Asterosaponins
  • Ca influx
  • Contractile force
  • Lethasterias nanimensis chelifera
  • Molluscan heart
  • Ouabain
  • Rat brain Na,K-ATPase
  • Spisula sachalinensis
  • Starfish sapogenins

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Stimulatory effects of starfish sapogenins (Asterias amurensis and Lethasterias nanimensis chelifera) on molluscan heart (Spisula sachalinensis). / Gorshkov, Boris A; Kapustina, Irina I.; Kicha, Alla A.; Aminin, Dmitry L.; Gorshkova, Irina A.

In: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Vol. 120, No. 2, 01.08.1998, p. 235-239.

Research output: Contribution to journalArticle

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