STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?

Henrique Lemos, Lei Huang, Tracy McGaha, Andrew L. Mellor

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalExpert Review of Clinical Immunology
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • DNA
  • STING
  • autoimmunity
  • cancer
  • immunity
  • immunotherapy
  • nanoparticles
  • tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'STING, nanoparticles, autoimmune disease and cancer: A novel paradigm for immunotherapy?'. Together they form a unique fingerprint.

  • Cite this