Streptococcal Pharyngitis: Comparison of Latex Agglutination and Throat Culture

Christopher B. White, Richard Harris, Inez Gonzales, Michael R. Weir, James W. Bass

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Abstract

Despite its imperfections, the throat culture remains the gold standard against which all rapid streptococcal antigen detection tests are compared. Using triple throat swabs, the accuracy of a rapid latex agglutination (LA) test and back up throat culture was determined and compared with a simultaneously obtained additional throat culture in children with suspected streptococcal pharyngitis. Although there was a 95 percent concordancy between throat cultures, the sensitivity of the throat culture was only 87 percent. Despite the LA test's lower sensitivity (78 percent), in this clinical population with a relatively low prevalence of positive throat cultures (19 percent), the predictive value of a negative LA test was only slightly lower than that of the throat culture (94-95 percent vs. 97 percent). Backup throat cultures are commonly recommended for patients with initially negative LA test results, but 10 percent of the patients with group A beta-hemolytic streptococci-positive throat cultures would have been undetected using this approach.

Original languageEnglish (US)
Pages (from-to)431-434
Number of pages4
JournalClinical Pediatrics
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 1988

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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White, C. B., Harris, R., Gonzales, I., Weir, M. R., & Bass, J. W. (1988). Streptococcal Pharyngitis: Comparison of Latex Agglutination and Throat Culture. Clinical Pediatrics, 27(9), 431-434. https://doi.org/10.1177/000992288802700904